Interesting scientific research on 57825-30-6

Here is just a brief introduction to this compound(57825-30-6)COA of Formula: C9H11Br, more information about the compound(1-(Bromomethyl)-4-ethylbenzene) is in the article, you can click the link below.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Buchynskyy, Andriy; Gillespie, J. Robert; Hulverson, Matthew A.; McQueen, Joshua; Creason, Sharon A.; Ranade, Ranae M.; Duster, Nicole A.; Gelb, Michael H.; Buckner, Frederick S. researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).COA of Formula: C9H11Br.They published the article 《Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors》 about this compound( cas:57825-30-6 ) in Bioorganic & Medicinal Chemistry. Keywords: aminoethyl benzyloxyphenyl benzamide derivative preparation Trypanosoma brucei; Hit-to-lead optimization; Human African Trypanosomiasis; Trypanosoma brucei inhibitor; “Sleeping Sickness”. We’ll tell you more about this compound (cas:57825-30-6).

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-Ph benzamides as a starting point for hit-to-lead medicinal chem. Eighty two analogs were prepared, which led to the identification of a set of highly potent N-(2-aminoethyl)-N-benzyloxyphenyl benzamides with the most potent compound 73 having an in vitro EC50 = 0.001 μM. The compounds displayed drug-like properties when tested in a number of in vitro assays. Compound 73 was orally bioavailable and displayed good plasma and brain exposure in mice, cured 2 out of 3 mice infected with Trypanosoma brucei in acute model when dosed orally at 50 mg/kg once per day for 4 days. Given its potent antiparasitic properties and its ease of synthesis, compound 73 represents a potential lead for the development of drug to treat Human African Trypanosomiasis.

Here is just a brief introduction to this compound(57825-30-6)COA of Formula: C9H11Br, more information about the compound(1-(Bromomethyl)-4-ethylbenzene) is in the article, you can click the link below.

Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider