Yamamoto, Yasuo; Kawanishi, Eiji; Koga, Yuichi; Sakamaki, Shigeki; Sakamoto, Toshiaki; Ueta, Kiichiro; Matsushita, Yasuaki; Kuriyama, Chiaki; Tsuda-Tsukimoto, Minoru; Nomura, Sumihiro published the article 《N-glucosides as human sodium-dependent glucose co-transporter 2 (hSGLT2) inhibitors》. Keywords: urinary glucose amino glycoside preparation human hyperglycemia structure activity; amino glycoside preparation antidiabetic human SGLT2 inhibitor pharmacokinetic; Diabetes; Glucoside; N-glucoside; SGLT2; Sodium-dependent glucose cotransporter.They researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Computed Properties of C9H11Br. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:57825-30-6) here.
Inhibition of renal sodium-dependent glucose co-transporter 2 (SGLT2) increases urinary glucose excretion (UGE), and thus reduces blood glucose levels in hyperglycemia. A series of N-glucosides was synthesized for biol. evaluation as human SGLT2 (hSGLT2) inhibitors. Among these compounds, N-glucoside 9d possessing an indole core structure showed good in vitro activity (IC50 = 7.1 nM against hSGLT2). Furthermore, 9d exhibited favorable in vivo potency with regard to UGE in rats based on good pharmacokinetic profiles.
I hope my short article helps more people learn about this compound(1-(Bromomethyl)-4-ethylbenzene)Computed Properties of C9H11Br. Apart from the compound(57825-30-6), you can read my other articles to know other related compounds.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider