The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-Bromo-5-phenyloxazole(SMILESS: BrC1=C(C2=CC=CC=C2)OC=N1,cas:740806-67-1) is researched.Reference of 2-Bromobenzo[d]thiazol-6-amine. The article 《Regioselective Palladium Cross-Coupling of 2,4-Dihalooxazoles: Convergent Synthesis of Trisoxazoles》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:740806-67-1).
A regioselective Suzuki-Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles, e.g. I, in high yield and in a min. number of steps.
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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider