So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Repta, A. J.; Baltezor, M. J.; Bansal, P. C. researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).SDS of cas: 19777-66-3.They published the article 《Utilization of an enantiomer as a solution to a pharmaceutical problem: application to solubilization of 1,2-bis(4-piperazine-2,6-dione)propane》 about this compound( cas:19777-66-3 ) in Journal of Pharmaceutical Sciences. Keywords: ICRF 159 solubilization enantiomer; piperazinedionepropane solubilization enantiomer. We’ll tell you more about this compound (cas:19777-66-3).
An enantiomer (R)(-)-I [24613-06-7] of the cytotoxic agent (±)-1,2-bis(4-piperazine-2,6-dione)propane [(±)-I] (ICRF 159) [21416-67-1] was utilized to overcome a solubility problem in the preparation of a solution suitable for i.v. use. The enantiomers (S)(+)-I [24584-09-6] and (R)(-)-I were prepared and were about five times more soluble and melted at about 40° lower than the racemic compound This study appears to be the 1st reported instance in which the difference in the phys. properties of a racemic compound and its enantiomers was utilized to improve a pharmaceutical formulation. The expected differences in the phys. properties of racemic solids and their corresponding enantiomers are discussed briefly in relation to the 3 racemic modifications known to exist.
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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider