Synthetic Route of C9H11Br. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery and Development of Thiazolo[3,2-a]pyrimidinone Derivatives as General Inhibitors of Bcl-2 Family Proteins. Author is Zhou, Bingcheng; Li, Xun; Li, Yan; Xu, Yaochun; Zhang, Zhengxi; Zhou, Mi; Zhang, Xinglong; Liu, Zhen; Zhou, Jiahai; Cao, Chunyang; Yu, Biao; Wang, Renxiao.
A class of compounds with a common thiazolo[3,2-a]pyrimidinone motif has been developed as general inhibitors of Bcl-2 family proteins. The lead compound was originally identified in a random screening of a small compound library using a fluorescence polarization-based competitive binding assay. Its binding to the Bcl-xL protein was further confirmed by 15N-HSQC NMR experiments Structural modifications on the lead compound were guided by the outcomes of mol. modeling studies. Among the 42 compounds obtained, a number of them exhibited much improved binding affinities to Bcl-2 family proteins as compared to the lead compound The most potent compound, BCL-LZH-40 (I), inhibited the binding of BH3 peptides to Bcl-xL, Bcl-2, and Mcl-1 with inhibition constants (Ki) of 17, 534, and 200 nM, resp.
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider