Safety of (S)-Propane-1,2-diamine dihydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Utilization of an enantiomer as a solution to a pharmaceutical problem: application to solubilization of 1,2-bis(4-piperazine-2,6-dione)propane. Author is Repta, A. J.; Baltezor, M. J.; Bansal, P. C..
An enantiomer (R)(-)-I [24613-06-7] of the cytotoxic agent (±)-1,2-bis(4-piperazine-2,6-dione)propane [(±)-I] (ICRF 159) [21416-67-1] was utilized to overcome a solubility problem in the preparation of a solution suitable for i.v. use. The enantiomers (S)(+)-I [24584-09-6] and (R)(-)-I were prepared and were about five times more soluble and melted at about 40° lower than the racemic compound This study appears to be the 1st reported instance in which the difference in the phys. properties of a racemic compound and its enantiomers was utilized to improve a pharmaceutical formulation. The expected differences in the phys. properties of racemic solids and their corresponding enantiomers are discussed briefly in relation to the 3 racemic modifications known to exist.
In addition to the literature in the link below, there is a lot of literature about this compound((S)-Propane-1,2-diamine dihydrochloride)Safety of (S)-Propane-1,2-diamine dihydrochloride, illustrating the importance and wide applicability of this compound(19777-66-3).
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider