The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Palladium-Catalyzed Alkenylation of Quinoline-N-oxides via C-H Activation under External-Oxidant-Free Conditions, the main research direction is palladium catalyst stereoselective regioselective alkenylation quinoline oxide.Formula: C9H7NO2.
The direct cross-coupling of quinoline-N-oxides with olefin derivatives has been realized using palladium acetate as the catalyst in the absence of external ligand and oxidant to give the corresponding 2-alkenylated quinolines and 1-alkenylated isoquinolines chemo- and regioselectively in 27-95% yield. The catalytic process is proposed to proceed via direct C-H bond activation of the quinoline-N-oxide with Pd(OAc)2 followed by Heck coupling with the olefin. The resultant N-oxide of the alkenylated quinoline can oxidize the reduced Pd(0) to regenerate the Pd(II) active species and simultaneously release the 2-alkenylated quinoline without using any external oxidants and reductants.
This literature about this compound(1127-45-3)Formula: C9H7NO2has given us a lot of inspiration, and I hope that the research on this compound(8-Hydroxyquinoline 1-oxide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider