So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Shuai; Xiao, Jun-Zhao; Li, Yan-Bo; Shi, Chang-Yun; Yin, Liang researched the compound: 1-(Bromomethyl)-4-ethylbenzene( cas:57825-30-6 ).Related Products of 57825-30-6.They published the article 《Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines》 about this compound( cas:57825-30-6 ) in Journal of the American Chemical Society. Keywords: chiral benzyldiarylphosphine sulfide preparation crystal structure; crystal structure chiral benzyldiarylphosphine sulfide bisphosphine copper bridging halide; mol structure chiral benzyldiarylphosphine sulfide bisphosphine copper bridging halide; bisphosphine copper bridging halide cage complex preparation crystal structure; phosphorus stereogenic chiral tertiary phosphine sulfide preparation. We’ll tell you more about this compound (cas:57825-30-6).
A Cu(I)-catalyzed asym. alkylation of HPAr1Ar2 with alkyl halides is uncovered, which provides an array of P-stereogenic phosphines in generally high yield and enantioselectivity. The electrophilic alkyl halides enjoy a broad substrate scope, including allyl bromides, propargyl bromide, benzyl bromides, and alkyl iodides. Also, 11 unsym. diarylphosphines (HPAr1Ar2) serve as competent pronucleophiles. The present methodol. is also successfully applied to catalytic asym. double and triple alkylation, and the corresponding products were obtained in moderate diastereo- and excellent enantioselectivities. Some 31P NMR experiments indicate that bulky HPPhMes exhibits weak competitively coordinating ability to the Cu(I)-bisphosphine complex, and thus the presence of stoichiometric HPAr1Ar2 does not affect the enantioselectivity significantly. Therefore, the high enantioselectivity in this reaction is attributed to the high performance of the unique Cu(I)-(R,RP)-TANIAPHOS complex in asym. induction. Finally, one monophosphine and two bisphosphines prepared by the present reaction are employed as efficient chiral ligands to afford three structurally diversified Cu(I) complexes, which demonstrates the synthetic utility of the present methodol.
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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider