In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Manganese-catalysed benzylic C(sp3)-H amination for late-stage functionalization, published in 2018-06-30, which mentions a compound: 57825-30-6, mainly applied to regioselective benzylic amination manganese perchlorophthalocyanine catalyst, Electric Literature of C9H11Br.
Reactions that directly install nitrogen into C-H bonds of complex mols. are significant because of their potential to change the chem. and biol. properties of a given compound Although selective intramol. C-H amination reactions are known, achieving high levels of reactivity while maintaining excellent site selectivity and functional-group tolerance remains a challenge for intermol. C-H amination. Here, we report a manganese perchlorophthalocyanine catalyst [MnIII(ClPc)] for intermol. benzylic C-H amination of bioactive mols. and natural products that proceeds with unprecedented levels of reactivity and site selectivity. In the presence of a Bronsted or Lewis acid, the [MnIII(ClPc)]-catalyzed C-H amination demonstrates unique tolerance for tertiary amine, pyridine and benzimidazole functionalities. Mechanistic studies suggest that C-H amination likely proceeds through an electrophilic metallonitrene intermediate via a stepwise pathway where C-H cleavage is the rate-determining step of the reaction. Collectively, these mechanistic features contrast with previous base-metal-catalyzed C-H aminations and provide new opportunities for tunable selectivities.
As far as I know, this compound(57825-30-6)Electric Literature of C9H11Br can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider