The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-2,2′,6,6′-Tetramethoxy-4,4′-bis(diphenylphosphino)-3,3′-bipyridine( cas:221012-82-4 ) is researched.SDS of cas: 221012-82-4.Wang, Zi-Xuan; Li, Bi-Jie published the article 《Construction of Acyclic Quaternary Carbon Stereocenters by Catalytic Asymmetric Hydroalkynylation of Unactivated Alkenes》 about this compound( cas:221012-82-4 ) in Journal of the American Chemical Society. Keywords: alkene acetylene iridium catalyst enantioselective regioselective chemoselective hydroalkynylation; alkyne stereoselective preparation; quaternary carbon stereocenter. Let’s learn more about this compound (cas:221012-82-4).
Quaternary carbon stereocenters are common structural motifs in organic synthesis. The construction of these stereocenters in a catalytic and enantioselective manner remains a prominent synthetic challenge. In particular, methods for the synthesis of alkyne-substituted quaternary carbon stereocenters are very rare. Previous catalytic systems for hydroalkynylation of alkenes create tertiary stereocenters. An iridium catalyzed asym. hydroalkynylation of nonactivated trisubstituted alkene is described. The hydroalkynylation of β,γ-unsaturated amides occurs with high regio- and enantioselectivities to afford alkyne-substituted acyclic quaternary carbon stereocenters. Computational and exptl. data suggest that the enantioselectivity is not only determined by the facial selectivity of the alkene but also by an alkene isomerization process. This strategy provides an efficient method to access alkyne-substituted acyclic quaternary carbon stereocenters with minimally functionalized starting materials.
As far as I know, this compound(221012-82-4)SDS of cas: 221012-82-4 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider