Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Nature Chemistry called Manganese-catalysed benzylic C(sp3)-H amination for late-stage functionalization, Author is Clark, Joseph R.; Feng, Kaibo; Sookezian, Anasheh; White, M. Christina, which mentions a compound: 57825-30-6, SMILESS is CCC1=CC=C(CBr)C=C1, Molecular C9H11Br, Reference of 1-(Bromomethyl)-4-ethylbenzene.
Reactions that directly install nitrogen into C-H bonds of complex mols. are significant because of their potential to change the chem. and biol. properties of a given compound Although selective intramol. C-H amination reactions are known, achieving high levels of reactivity while maintaining excellent site selectivity and functional-group tolerance remains a challenge for intermol. C-H amination. Here, we report a manganese perchlorophthalocyanine catalyst [MnIII(ClPc)] for intermol. benzylic C-H amination of bioactive mols. and natural products that proceeds with unprecedented levels of reactivity and site selectivity. In the presence of a Bronsted or Lewis acid, the [MnIII(ClPc)]-catalyzed C-H amination demonstrates unique tolerance for tertiary amine, pyridine and benzimidazole functionalities. Mechanistic studies suggest that C-H amination likely proceeds through an electrophilic metallonitrene intermediate via a stepwise pathway where C-H cleavage is the rate-determining step of the reaction. Collectively, these mechanistic features contrast with previous base-metal-catalyzed C-H aminations and provide new opportunities for tunable selectivities.
As far as I know, this compound(57825-30-6)Reference of 1-(Bromomethyl)-4-ethylbenzene can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider