Product Details of 1127-45-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Regioselective Metal-Free C2-H Arylation of Quinoline N-Oxides with Aryldiazonium Salts/Anilines under Ambient Conditions. Author is Kumar, Rakesh; Dhiman, Ankit Kumar; Sharma, Upendra.
Herein, a base-promoted direct C2-H arylation of quinoline N-oxides with aryldiazonium salts under metal-free conditions is reported. This reaction avoids the need for an oxidant, metal catalyst, or inert atm. and proceeds through a highly regioselective C-H bond functionalization to provide a series of C2-arylated quinoline N-oxides. Abundantly available amines (anilines and heteroaryl amines) can also be employed as arylating agents through an in situ diazotization process, thereby affording a library of diverse 2-arylquinoline N-oxides in moderate-to-good yields. The synthesized 2-arylated quinoline N-oxides were further converted into C8-substituted quinolines to demonstrate the applicability of this catalytic approach. A radical pathway is proposed for the C2 arylation, based on a preliminary mechanistic study.
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Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider