So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hsu, Fu-Lian; Hamada, Akihiko; Booher, Mark E.; Fuder, H.; Patil, P. N.; Miller, Duane D. researched the compound: (S)-Propane-1,2-diamine dihydrochloride( cas:19777-66-3 ).Safety of (S)-Propane-1,2-diamine dihydrochloride.They published the article 《Optically active derivatives of imidazolines. α-Adrenergic blocking properties》 about this compound( cas:19777-66-3 ) in Journal of Medicinal Chemistry. Keywords: imidazoline stereoisomer preparation adrenergic blocker. We’ll tell you more about this compound (cas:19777-66-3).
The title compounds I (R and R1 = H, Me, or PhCH2; R2 = 1-naphthylmethyl, PhCH2, or 2,6-dichloroaniline) as salts were prepared from an optically active 1,2-diamine-2HCl and an imino ester HCl, and converted to a stable solid salt. I were evaluated for α-adrenergic activity on rabbit aortic strips. Compared to naphazoline or tolazoline, substitution of a Me or PhCH2 at the 4 position of the imidazoline ring resulted in moderate α-blocking activity with no apparent stereoselectivity with such substitution.
After consulting a lot of data, we found that this compound(19777-66-3)Safety of (S)-Propane-1,2-diamine dihydrochloride can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider