Month: April 2022

Synthetic Route of C7H5ClN4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Chloro-6-(1H-imidazol-1-yl)pyrimidine, is researched, Molecular C7H5ClN4, CAS is 114834-02-5, about Selective mono-amination of dichlorodiazines. Author is Sengmany, Stephane; Lebre, Julie; Le Gall, Erwan; Leonel, Eric.

3,6-Dichloropyridazine, 4,6-dichloropyrimidine, 2,4-dichloropyrimidine, and 3,5-dichloropyridazine underwent chemoselective monosubstitution reactions with amines using triethylamine as a base in ethanol at either ambient temperature or reflux to give monoamino monochloro pyridazines and pyrimidines. The methodol. is general and efficient despite noticeable differences in reactivity between diazines; while dichloropyridazine and dichloropyrazine require several hours of heating at reflux for the reaction to proceed, dichloropyrimidines reach completion within minutes at room temperature

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Syntheses of 8-hydroxyquinoline N-oxide and its metallic complex salts》. Authors are Murase, Ichiro.The article about the compound:8-Hydroxyquinoline 1-oxidecas:1127-45-3,SMILESS:OC1=CC=CC2=CC=C[N+]([O-])=C12).Related Products of 1127-45-3. Through the article, more information about this compound (cas:1127-45-3) is conveyed.

8-Hydroxyquinoline N-oxide (IH) was obtained by the direct oxidation of 8-hydroxyquinoline with AcOH + 30% H2O2 or phthalic monoperacid as yellow crystals m. 138°. Greenish yellow CuI2.H2O, greenish black (MnI)2O.H2O and brownish black FeI3 were obtained. Fe(II), Ni, Co, and Zn do not form complexes.

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Category: quinoxaline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about From Mesocates to Helicates: Structural, Magnetic and Chiro-Optical Studies on Nickel(II) Supramolecular Assemblies Derived from Tetradentate Schiff Bases. Author is Mayans, Julia; Font-Bardia, Merce; Di Bari, Lorenzo; Arrico, Lorenzo; Zinna, Francesco; Pescitelli, Gennaro; Escuer, Albert.

The systematic reactions of a family of tetradentate pyridyl/imine and quinolyl/imine racemic or enantiopure Schiff bases with Ni(NO3)2 or Ni(ClO4)2 in the presence of sodium azide yielded, as a function of the starting racemic, chiral or achiral base, a set of chiral, meso or achiral complexes. In all cases, the compounds consist of two NiII cations linked by a double azido bridge in its end-on coordination mode. All the dimers exhibit a mesocate supramol. structure and one of them, the unprecedented mix of helicate and mesocate in 2:1 ratio. The transition from mesocate to helicate conformation was reached by tuning the flexibility of the central spacers of the Schiff bases and the size of the substituents. Electronic CD (ECD) studies were performed for two pairs of enantiomers and interpreted by DFT calculations Susceptibility measurements show a ferromagnetic coupling between the NiII cations mediated by the end-on azido bridges.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Structures of pyridine and quinoline-N-oxide, published in 1970, which mentions a compound: 1127-45-3, Name is 8-Hydroxyquinoline 1-oxide, Molecular C9H7NO2, Synthetic Route of C9H7NO2.

8-Hydroxyquinoline 1-oxide (I) and 2-(hydroxymethyl)pyridine 1-oxide (II) exhibited lengthened N-O bond distances (1.333 and 1.332 Å) due to delocalization of the nonbonding electron on the O as a result of H bonding. The H bond between the hydroxyl H and the dative O is intramol. (1.42 Å long) in I and intermol. in II (1.99 Å long). The pyridine and quinoline moieties are planar. Crystals have monoclinic symmetry, space group P21/c, and Z = 4. Compound, lattice constants a, b, c, and cos. β are: I, 12.136, 4.921, 13.138 Å, -0.3376; II, 7.079, 8.046, 10.599 Å, -0.2254.

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Safety of 1-(Bromomethyl)-4-ethylbenzene. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. Author is Imamura, Masakazu; Nakanishi, Keita; Suzuki, Takayuki; Ikegai, Kazuhiro; Shiraki, Ryota; Ogiyama, Takashi; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki.

A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative I (R =H) was found to have potent inhibitory activity against SGLT2 and good selectivity vs. SGLT1. Through further optimization of 14a, a novel benzothiophene derivative I (R = F) (ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

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Product Details of 19777-66-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Propane-1,2-diamine dihydrochloride, is researched, Molecular C3H12Cl2N2, CAS is 19777-66-3, about Optically active complexes of Schiff bases. I. Syntheses and properties of optically active tetradentate Schiff bases.

Reproducible syntheses and resolutions of 1,2-diamines were reported. Isomeric Schiff bases were prepared by condensation of 1 mole of (+),(-), or meso-1,2-diamine with 2 moles MeCOCH2COMe, salicylaldehyde or (+)-hydroxymethylenecamphor and identified by NMR and ir spectra. Configurational studies of the Schiff bases were made on the basis of ORD and CD spectra.

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COA of Formula: C9H7NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about Acid reaction and ionization constants of 8-hydroxyquinoline-N-oxide. Author is Al-Zagoum, M. N.; Warren, C. G..

The constants for the acid reactions of 8-hydroxyquinoline-N-oxide were determined at 25° and M ionic strength. The 1st ionization constant for the cation of oxine-N-oxide, H2Q+, was 0.0486 ± 0.0004. The constant for the acid reaction for the 2nd ionization of the above compound was 176 kw ± 15, where kw is the ion product of water. This constant is for the ionization of oxine-N-oxide which produces H ions and a combination of basic forms including the anion and the Na salt. The 1st ionization constant was determined by potentiometric measurements. The 2nd ionization was studied by solvent extraction methods. The reagent was synthesized by a modified K. Ramaiah and V. R. Srinivasan (1962) procedure.

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Synthetic Route of C9H7NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 8-Hydroxyquinoline 1-oxide, is researched, Molecular C9H7NO2, CAS is 1127-45-3, about catena-Poly[[[diaquabis(8-hydroxyquinoline N-oxide-κO1)cobalt(II)]-μ-2,5-dimethylpyrazine 1,4-dioxide-κ2O1:O4] bis(perchlorate)]. Author is Gu, Li Qin; Li, Jin Min.

In the title complex, {[Co(C6H8N2O2)(C9H7NO2)(H2O)2](ClO4)2}n, the CoII ion lies on an inversion center and is coordinated in a slightly distorted octahedral environment. The 2,5-dimethylpyrazine 1,4-dioxide ligand, which also lies on an inversion center, acts as a bridging ligand, linking symmetry-related CoII ions [Co…Co = 8.669 (3) Å] and forming one-dimensional chains along the b axis. In the crystal structure, these chains are linked by intermol. aqua-perchlorate O-H…O hydrogen bonds, forming two-dimensional layers which are in turn connected into a three-dimensional network via π-π stacking interactions between quinoline rings, with a centroid-centroid distance of 3.580 (3) Å. An intermol. O-H…Cl interaction is also present. Crystallog. data are given.

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Recommanded Product: 1-(Bromomethyl)-4-ethylbenzene. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(Bromomethyl)-4-ethylbenzene, is researched, Molecular C9H11Br, CAS is 57825-30-6, about Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus. Author is Imamura, Masakazu; Nakanishi, Keita; Suzuki, Takayuki; Ikegai, Kazuhiro; Shiraki, Ryota; Ogiyama, Takashi; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki.

A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative I (R =H) was found to have potent inhibitory activity against SGLT2 and good selectivity vs. SGLT1. Through further optimization of 14a, a novel benzothiophene derivative I (R = F) (ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Thermal investigation of metal fluoroberyllate hydrates and metal fluoride hydrates, published in 1981-08-16, which mentions a compound: 13940-83-5, Name is Nickel(ii)fluoridetetrahydrate, Molecular F2H8NiO4, Electric Literature of F2H8NiO4.

The thermal decompositions of MBeF4.xH2O and MF2.xH2O, where M = Ni(II), Co(II) or Cu(II) and x = 0-6, were carried out using a MOM derivatograph. Dehydration takes place in multiple steps. Anhydrous fluoroberyllates dissociate first to MF2 and BeF2 and then decompose to MO and BeO in 2 steps. Metal fluorides give ultimately oxyfluoride in one step. None of the intermediate hydrates is thermally stable, except CuF2.2H2O. The probable mechanisms of thermal decomposition are reported. Pyrolyzed products were characterized by elemental anal. and x-ray powder patterns. The enthalpy change is reported for each decomposition step.

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