Month: October 2022

On November 21, 1995, Ellis, Michael J.; Lloyd, Douglas; McNab, Hamish; Walker, Marion J. published an article.Formula: C8H10N2 The title of the article was Gas-phase pyrolysis of 2,3-dihydro-1,4-diazepines: involvement of the saturated portion of the ring in chemical reactions and novel cis-trans isomerization of a fused ring system. And the article contained the following:

Flash vacuum pyrolysis of 2,3-dihydro-1,4-diazepines in the range 450-550 °C involves interaction of the saturated portion of the mol. with the vinamidine system and causes 1,5-hydrogen shifts which have been established by deuterium labeling experiments; at higher temperatures, ring contraction occurs to give pyrazines as major products. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to isomerization pyrolysis dihydrodiazepine, ring contraction pyrolysis dihydrodiazepine, hydrogen shift pyrolysis dihydrodiazepine, mechanism pyrolysis dihydrodiazepine, Physical Organic Chemistry: Degradation Reactions, Including Mass Spectral Fragmentation and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On June 30, 2000, Wei, Shuping; Zhang, Hua; Xu, Xiaobin; Yang, Yayan published an article.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline The title of the article was Natural-existed pyrazine derivatives and their application to flavors. And the article contained the following:

A series of natural-existed pyrazine derivatives were studied in relation to regularities between their aroma and structure, and also showed some application as flavorant. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

The Article related to pyrazine derivative flavor application, Food and Feed Chemistry: Additives, Sweeteners, Flavorings, Condiments, and Confectionery and other aspects.Recommanded Product: 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On April 30, 2011, Khanafari, A.; Olia, M. Seyed Jafari; Sharifnia, F. published an article.SDS of cas: 34413-35-9 The title of the article was Bioconversion of essential oil from plants with eugenol bases to vanillin by Serratia marcescens. And the article contained the following:

Essential oils extraction from native or collective plants with eugenol basses such as Eugenia caryophyllata and Ocimum basilicum and bio-transformation to vanillin by Serratia marcescens (ATCC 13880) was investigated. The oils were obtained by steam distillation and were analyzed by UV and GC-MS. Essential oils with eugenol bases was added to resting phase of bacterium growth curve with final concentration of 20 gL-1 and incubated at 27°C and 150 rpm, for 24 h to bioconversion to vanillin. Crystalline structure of vanillin was isolated and confirmed by GC-MS. Forthy-three and one hundred and fifteen compounds were identified in essential oil of Eugenia caryopyllata by using first and second methods and eugenol was determined as the major component with 88.205 % and 54.628 % resp. Eugenol in essential oil of Ocimum basilicum was rare. The highest vanillin concentration, 0.6 gL-1, was obtained with 46 % purity from flower buds of Eugenia caryopyllata. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).SDS of cas: 34413-35-9

The Article related to eugenia ocimum essential oil eugenol vanillin serratia bioconversion, Food and Feed Chemistry: Additives, Sweeteners, Flavorings, Condiments, and Confectionery and other aspects.SDS of cas: 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On October 14, 2010, Jiang, Huanfeng; Chen, Huoji; Wang, Azhong; Liu, Xiaohang published an article.Synthetic Route of 34413-35-9 The title of the article was Palladium-catalyzed acetoxylation of sp3 C-H bonds using molecular oxygen. And the article contained the following:

Mol. oxygen as oxidant to promote palladium-catalyzed acetoxylation of sp3 C-H bonds to afford α-oxygenated products is reported. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Synthetic Route of 34413-35-9

The Article related to palladium catalyzed acetoxylation mol oxygen, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Synthetic Route of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On April 30, 1986, Houminer, Y.; Southwick, E. W.; Williams, D. L. published an article.Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline The title of the article was Preparation of monoacylpyrazines. And the article contained the following:

Homolytic acylation of pyrazine and alkylpyrazines by aldehydes, as a source of an acyl radical, gives mainly monoacylation products. The reactions proceed in reasonable yields and provide a new route to pyrazine ketones. Thus, stirring pyrazine with EtCHO in water in the presence of H2SO4, t-BuOOH, and FeSO4 gave 29% pyrazine I. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline

The Article related to acylpyrazine, pyrazine acylation aldehyde, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application In Synthesis of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On March 23, 2017, Ucar, Sefa; Essiz, Selcuk; Dastan, Arif published an article.HPLC of Formula: 34413-35-9 The title of the article was Bromination of quinoxaline and derivatives: Effective synthesis of some new brominated quinoxalines. And the article contained the following:

The synthesis of brominated quinoxaline derivatives starting from several kinds of quinoxaline by different bromination strategies was studied. First the synthesis of some brominated quinoxalines was accomplished along with the development of an alternative and effective synthesis of some known compounds A new, clean, and effective synthetic method for selective reduction of quinoxaline to 1,2,3,4-tetrahydroquinoxaline was also developed. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).HPLC of Formula: 34413-35-9

The Article related to brominated quinoxaline preparation, quinoxaline bromination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.HPLC of Formula: 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On March 15, 2022, Liu, Fu; Chen, Li-Ning; Chen, Ai-Min; Ye, Zhi-Peng; Wang, Zhi-Wei; Liu, Zhi-Lin; He, Xian-Chen; Li, Shu-Hui; Xia, Peng-Ju published an article.Computed Properties of 34413-35-9 The title of the article was Mechanochemical Synthesis of 2-Arylquinoxalines and 3-Arylquinoxalin-2(1H)-ones via Aryldiazonium Salts. And the article contained the following:

A green synthesis strategy of 2-arylquinoxalines I [Ar = Ph, 4-ClC6H4, 4-NCC6H4, etc.] and 3-arylquinoxalin-2(1H)-ones II [Ar = 4-MeC6H4, 4-FC6H4, 3-ClC6H4, etc.] via ball milling, which could avoid copious solvent waste, was accomplished in this work. Aryl radicals were produced from aryldiazonium salts by using a solvent-free or catalyst-free single electron transfer process induced by mech. force, afforded a series of 2-arylquinoxalines and 3-arylquinoxalin-2(1H)-ones with 28%-85 yield. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Computed Properties of 34413-35-9

The Article related to arylquinoxaline green preparation, arylquinoxalinone green preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Computed Properties of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On March 20, 2008, Kumar, Ajeet; Kumar, Santosh; Saxena, Amit; De, Arnab; Mozumdar, Subho published an article.Formula: C8H10N2 The title of the article was Ni-nanoparticles: An efficient catalyst for the synthesis of quinoxalines. And the article contained the following:

Biol. active quinoxalines were efficiently synthesized in excellent yields and in less reaction time using inexpensive, monodispersed and easily recyclable Ni-nanoparticles. In order to elucidate the role of the Ni-nanoparticles, a control reaction was conducted using glyoxal and o-phenylenediamine in acetonitrile in the absence of Ni-nanoparticles. Quinoxaline was formed in around 10 h with a 30% yield. However, the same reaction carried out in acetonitrile using 10 mol.% of Ni-nanoparticles (14-18 nm) at 25° and stirred under N2 gave quinoxaline in quant. yield in 10 min. The separation of the product was facile and the catalyst could be separated and recycled by mild centrifugation. This method is very quick, avoids the use of expensive reagents, high temperatures (the reaction takes place at room temperature) and leads to excellent yield. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to quinoxaline preparation glyoxal phenylenediamine nickel nanoparticle catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On August 9, 2012, Lankau, Hans-Joachim; Langen, Barbara; Grunwald, Christian; Hoefgen, Norbert; Stange, Hans; Dost, Rita; Egerland, Ute published a patent.Recommanded Product: 62163-09-1 The title of the patent was Preparation of (1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases for treating CNS disorders and other diseases. And the patent contained the following:

The invention relates to (1,2,4)triazolo[4,3-a]quinoxaline derivatives of Formula I (wherein R1 is Ph, 2-pyridyl, 3-pyridyl or 4-pyridyl, all optionally substituted; R2 is H or (un)substituted C1-4 alkyl; R3, R4, R5 and R6 are independently H, halo, (un)substituted C1-4 alkyl, etc.) that are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases. Synthetic procedures for preparing I are exemplified. Example compound II was prepared in a 5-step synthesis that culminates in cyclization of intermediate 2-chlorobenzoic acid N’-(7-chloro-3-methylquinoxalin-2-yl)hydrazide. In assays measuring inhibition of recombinant PDE10A and PDE2A (expressed in baculovirus/SF21 cells), II had IC50 values of 0.045 and 0.003 μM, resp. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Recommanded Product: 62163-09-1

The Article related to triazoloquinoxaline derivative preparation inhibitor phosphodiesterase treatment cns disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On April 1, 2022, Song, Shengjie; Shi, Xiangjun; Zhu, Yunsheng; Ren, Quanlei; Zhou, Peng; Zhou, Jiadi; Li, Jianjun published an article.Reference of 5,6,7,8-Tetrahydroquinoxaline The title of the article was Electrochemical Oxidative C-H Arylation of Quinoxalin(on)es with Arylhydrazine Hydrochlorides under Mild Conditions. And the article contained the following:

A practical and scalable protocol for electrochem. arylation of quinoxalin(on)es with arylhydrazine hydrochlorides under mild conditions was developed. This method exhibited high efficiency, easy scalability, and broad functional group tolerance. Various quinoxalin(on)es and arylhydrazines underwent this transformation smoothly in an undivided cell, providing the corresponding aryl-substituted quinoxalin(on)es in moderate to good yields. A radical mechanism was involved in this arylation reaction. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Reference of 5,6,7,8-Tetrahydroquinoxaline

The Article related to quinoxaline arylhydrazine hydrochloride electrochem oxidative arylation, arylquinoxaline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider