Minisci, Francesco; Gardini, G. P.; Galli, Remo; Bertini, F. published the artcile< New selective type of aromatic substitution: homolytic amidation>, SDS of cas: 5182-90-1, the main research area is heterocycle nitrogen homolytic amidation; homolytic amidation nitrogen heterocycle; amidation homolytic nitrogen heterocycle; nitrogen heterocycle homolytic amidation; heterocycle nitrogen homolytic amidation; carbamoylation homolytic nitrogen heterocycle; carbamoyl pyridines pyrazines; pyridines carbamoyl pyrazines; pyrazines carbamoyl pyridines; thiazoles imidazoles benzimidazoles amidation; imidazoles benzimidazoles thiazoles amidation; benzimidazoles imidazoles thiazoles amidation; carbamoyl radical nucleophilic character.
I, II (at least one of R1 and R2 is CONH2), and III are prepared by carbamoylation. Thus, 34% H2O2 soin. is added to quinoxaline and concentrated H2SO4 in HCONH2 at 10-15°. FeSO4.7H2O is added simultaneously, to give 97% 2-quinoxalinecarboxamide. Similarly prepared are I (R = H) and the following II (R, R1, and R2 given): H, CONH2, CONH2; H, CONH2, Et; (RR =)CH:CHCH:CH, CONH2, CONH2; (RR =) CH:CHCH:CH, CONH2, Me; (RR =) CH:CHCH:CH, Me, CONH2. Also prepared were 1-carbamoyl-isoquinoline, III (R = S), and III (R = NH).
Tetrahedron Letters published new progress about 5182-90-1. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, SDS of cas: 5182-90-1.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider