Reinhart, Peter H.; Kaltenbach, Linda S.; Essrich, Christian; Dunn, Denise E.; Eudailey, Joshua A.; DeMarco, C. Todd; Turmel, Gregory J.; Whaley, Jennifer C.; Wood, Andrew; Cho, Seongeun; Lo, Donald C. published the artcile< Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay>, Synthetic Route of 163769-88-8, the main research area is Huntington disease antiinflammatory target brain slice screening assay.
Huntington’s disease (HD) is a late-onset, neurodegenerative disease for which there are currently no cures nor disease-modifying treatments. Here we report the identification of several potential anti-inflammatory targets for HD using an ex vivo model of HD that involves the acute transfection of human mutant huntington-based constructs into rat brain slices. This model recapitulates key components of the human disease, including the formation of intracellular huntington protein (HTT)-containing inclusions and the progressive neurodegeneration of striatal neurons-both occurring within the native tissue context of these neurons. Using this “”high-throughput biol.”” screening platform, we conducted a hypothesis-neutral screen of a collection of drug-like compounds which identified several anti-inflammatory targets that provided neuroprotection against HTT fragment-induced neurodegeneration. The nature of these targets provide further support for non-cell autonomous mechanisms mediating significant aspects of neuropathogenesis induced by mutant HTT fragment proteins.
Neurobiology of Disease published new progress about Adenosine A2A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 163769-88-8 belongs to class quinoxaline, and the molecular formula is C22H21N3O2, Synthetic Route of 163769-88-8.
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Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider