Sangkanu, Suthinee; Rukachaisirikul, Vatcharin; Suriyachadkun, Chanwit; Phongpaichit, Souwalak published the artcile< Evaluation of antibacterial potential of mangrove sediment-derived actinomycetes>, Related Products of 5182-90-1, the main research area is sequence Streptomyces Staphylococcus Acinetobacter Chromobacterium antibacterial violacein; Anti-biofilm; Anti-violacein production; Antibacterial activity; Bioactive metabolites; Mangrove-derived actinomycetes; Streptomyces.
Actinomycetes are well-known as the source of bioactive metabolites. In this work, 16 out of 118 (13.6%) isolates of mangrove sediment-derived actinomycetes showed potential antibacterial activity against at least one bacterial strain. Five extracts from isolates AMA11, AMA12 and AMA21 exhibited a broad spectrum antibacterial activity against Staphylococcus aureus ATCC25923, Staphylococcus epidermidis ATCC35984, methicillin-resistant S. aureus (MRSA) SK1, Acinetobacter baumannii NPRC004 and Escherichia coli ATCC25922. Et acetate extract from the cells of AMA11 (AMA11CE) showed high activity against S. aureus and MRSA with the lowest min. inhibitory concentration (MIC) of 0.5μg ml-1. At concentration of four times its MIC, AMA11CE destroyed MRSA cells as analyzed by the SEM. In addition, AMA11CE, Et acetate extract from the culture broth of AMA12 (AMA12BE), AMA12CE and AMA21CE reduced violacein production in Chromobacterium violaceum. Furthermore, at concentrations lower than 10μg ml-1, all five extracts inhibited biofilm formation by S. epidermidis ATCC35984. The chem. anal. of the most active fraction from AMA11CE by GC-MS revealed the presence of 3-nitro-1,2-benzenedicarboxylic acid, hexadecanoic acid, quinoxaline-2-carboxamide and pentadecanoic acid. The 16S rDNA sequencing anal. revealed that these three potential isolates belonged to the genus Streptomyces. The results revealed that the actinomycetes from mangrove environment would be a good source of bioactive metabolites against pathogenic bacteria.
Microbial Pathogenesis published new progress about Acinetobacter baumannii. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Related Products of 5182-90-1.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider