Lee, Hong Geun; Milner, Phillip J.; Placzek, Michael S.; Buchwald, Stephen L.; Hooker, Jacob M. published the artcile< Virtually Instantaneous, Room-Temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes>, Electric Literature of 23088-24-6, the main research area is cyanation carbon 11 aryl compound biaryl phosphine palladium catalyst; aryl nitrile carbon 11 labeled preparation.
A new radiosynthetic protocol for the preparation of [11C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L·Pd(Ar)X complexes (L = biaryl phosphine) with [11C]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [11C]nitrile-containing pharmaceuticals, e.g., [11C]citalopram, were prepared with high radiochem. efficiency.
Journal of the American Chemical Society published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation) ([11C]-labeled). 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Electric Literature of 23088-24-6.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider