Li, Yi-Na; Li, Xue-Lin; Wu, Jin-Bo; Jiang, Hong; Liu, Yunmei; Guo, Yu; Zeng, Yao-Fu; Wang, Zhen published the artcile< Metal-free regioselective nitration of quinoxalin-2(1H)-ones with tert-butyl nitrite>, Reference of 89898-96-4, the main research area is nitro quinoxalinone preparation regioselective; quinoxalinone tert butyl nitrite metal free nitration.
A metal-free coupling of quinoxalin-2(1H)-ones with tert-Bu nitrite has been developed. Distinctly from the previous functionalization of quinoxalin-2(1H)-ones, this nitration reaction took place selectively at the C7 or C5 position of the Ph ring, affording a series of 7-nitro and 5-nitro quinoxalin-2(1H)-ones in moderate to good yields. Preliminary mechanistic studies revealed that the reaction may involve a radical process.
Organic & Biomolecular Chemistry published new progress about Coupling reaction, regioselective. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, Reference of 89898-96-4.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider