Day: October 14, 2022

Climent, M. J.; Corma, A.; Hernandez, J. C.; Hungria, A. B.; Iborra, S.; Martinez-Silvestre, S. published the artcile< Biomass into chemicals: One-pot two- and three-step synthesis of quinoxalines from biomass-derived glycols and 1,2-dinitrobenzene derivatives using supported gold nanoparticles as catalysts>, Recommanded Product: 6-Quinoxalinecarbonitrile, the main research area is vicinal diol phenylenediamine gold nanoparticle oxidation cyclocondensation catalyst; dinitrobenzene vicinal diol gold nanoparticle reduction oxidation cyclocondensation catalyst; quinoxaline preparation.

An efficient and selective one-pot two-step method, for the synthesis of quinoxalines by oxidative coupling of vicinal diols with 1,2-phenylenediamine derivatives, has been developed by using gold nanoparticles supported on nanoparticulated ceria (Au/CeO2) or hydrotalcite (Au/HT) as catalysts and air as oxidant, in the absence of any homogeneous base. Reaction kinetics shows that the reaction controlling step is the oxidation of the diol to α-hydroxycarbonyl compound Furthermore, a one-pot three-step synthesis of 2-methylquinoxaline starting from 1,2-dinitrobenzene and 1,2-propanediol has been successfully carried out with 98% conversion and 83% global yield to the final product.

Journal of Catalysis published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Recommanded Product: 6-Quinoxalinecarbonitrile.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

He, Zeng-Yang; Huang, Chao-Fan; Tian, Shi-Kai published the artcile< Highly Regioselective Carbamoylation of Electron-Deficient Nitrogen Heteroarenes with Hydrazinecarboxamides>, SDS of cas: 5182-90-1, the main research area is regioselective carbamoylation electron deficient nitrogen heteroarene hydrazinecarboxamide copper catalysis.

The use of hydrazinecarboxamides as a new class of carbamoylating agents has been established through the dehydrazinative Minisci reaction of electron-deficient nitrogen heteroarenes. A wide range of electron-deficient nitrogen heteroarenes, including isoquinoline, quinoline, pyridine, phenanthridine, quinoxaline, and phthalazine, underwent copper/acid-catalyzed oxidative carbamoylation with hydrazinecarboxamide hydrochlorides to afford structurally diverse nitrogen-heteroaryl carboxamides as single regioisomers in moderate to excellent yields. The functional group tolerance was substantially demonstrated in the direct carbamoylation of quinine obviating multistep sequences involving protecting groups and prefunctionalization of the heterocycle.

Organic Letters published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, SDS of cas: 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Khalymbadzha, Igor A.; Fatykhov, Ramil F.; Chupakhin, Oleg N.; Charushin, Valery N.; Tseitler, Tatiana A.; Sharapov, Ainur D.; Inytina, Anna K.; Kartsev, Victor G. published the artcile< Transition-Metal-Free C-C Coupling of 5,7-Dihydroxybenzopyrones with Quinoxalones and Pteridinones>, COA of Formula: C8H5N3O3, the main research area is dihydroxycoumarin quinoxalone regioselective chemoselective nucleophilic substitution oxidation green chem; dihydroxy oxochromenyl quinoxalinone preparation; pteridinone dihydroxycoumarin regioselective chemoselective nucleophilic substitution oxidation green chem; oxochromenyl tetrahydropteridinedione dihydroxy preparation.

A new synthetic protocol for nucleophilic substitution of hydrogen in quinoxalones and pteridinones by the action of 5,7-dihydroxycoumarins and related m-dihydroxybenzene compounds were developed. The C-C coupling reaction proved to proceed smoothly under rather mild conditions, thus giving the corresponding C-H functionalized products in good yields. The advantages of this environmentally benign protocol were high regio- and chemoselectivity and an easy workup procedure. Direct incorporation of the coumarin moiety into the pyrazine ring in pteridines or quinoxalines provided a short pathway to pyrazine-coumarin hybrid compounds

Synthesis published new progress about C-C bond formation. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, COA of Formula: C8H5N3O3.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Caronna, Tullio; Gambarotti, Cristian; Mele, Andrea; Pierini, Monica; Punta, Carlo; Recupero, Francesco published the artcile< A green approach to the amidation of heterocyclic bases: the use of sunlight and air>, Recommanded Product: Quinoxaline-2-carboxamide, the main research area is green chem amidation heterocyclic base sunlight.

A easy and environmentally friendly method for the photochem. functionalization of the heterocyclic bases is described. The selective introduction of the amido group of formamide, using sunlight and air in the presence of TiO2, has allowed to obtain the desired products in mild conditions with high conversions. The comparison of these results with those previously reported, in the presence of H2O2 instead of air, clarifies some aspects of the reaction mechanism.

Research on Chemical Intermediates published new progress about Amidation. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Recommanded Product: Quinoxaline-2-carboxamide.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nasielski, J.; Rypens, C. published the artcile< 6-Nitro-2,3-dipiperidinoquinoxaline: its unexpected formation from 2-chloro-7-nitroquinoxaline>, SDS of cas: 89898-96-4, the main research area is chloronitroquinoxaline substitution piperidine; nitrodipiperidinoquinoxaline.

Excess piperidine and 2-chloro-7-nitroquinoxaline I (R=Cl, R1=H) in di-Et ether give large amounts of the unexpected disubstitution product 6-nitro-2,3-dipiperidinoquinoxaline I (R=R1=piperidino). The mechanism of this very unusual nucleophilic substitution of hydrogen is suggested to involve the oxidation of the dipiperidinodihydroquinoxaline II ( R = piperidino) by dissolved oxygen.

Tetrahedron Letters published new progress about Substitution reaction. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, SDS of cas: 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Wozniak, Marian; Baranski, Andrzej; Nowak, Krystyna; Poradowska, Henryka published the artcile< Regioselectivity of the amination of some nitroquinoxalines by liquid ammonia/potassium permanganate>, Recommanded Product: 2-Chloro-6-nitroquinoxaline, the main research area is regioselective amination nitroquinoxaline; quinoxaline nitro regioselective amination.

5- And 6-nitroquinoxalines and some of their derivatives are aminated in a liquid NH3 solution of KMnO4 to yield the corresponding 2- and/or 3- and/or 5-amino compounds Quantum-chem. calculations are made to explain the regioselectivity of the amination reactions.

Liebigs Annalen der Chemie published new progress about Amination, regioselective. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Recommanded Product: 2-Chloro-6-nitroquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Takai, Hitoshi; Odani, Akira; Sasaki, Yoshio published the artcile< Studies on heterocyclic carbon-13 magnetic resonance spectroscopy. XI. Nitrogen heterocycles. (1). 6-Substituted quinoline and quinoxaline derivatives>, COA of Formula: C9H5N3, the main research area is carbon NMR quinoline quinoxaline; LFER NMR heterocycle.

The assignment of 13C NMR chem. shifts of 6-substituted quinoline and quinoxaline derivatives were confirmed, and the additivity rules of 13C chem. shifts of 2-substituted naphthalene derivatives were approved for both 6-substituted quinoline and quinoxaline derivatives The correlation coefficient of meta-like positions is promoted by the linear combinations of chem. shifts at the corresponding meta position of 2-substituted naphthalene derivatives and substituent constants σπ.

Chemical & Pharmaceutical Bulletin published new progress about Linear free energy relationship. 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, COA of Formula: C9H5N3.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Wang, Jiayang; Sun, Bin; Zhang, Liang; Xu, Tengwei; Xie, Yuanyuan; Jin, Can published the artcile< Visible-light-induced trifluoromethylation of quinoxalin-2(1H)-ones under photocatalyst-free conditions>, Synthetic Route of 89898-96-4, the main research area is trifluoromethylquinoxalinone regioselective green preparation; quinoxalinone sodium trifluoromethanesulfinate trifluoromethylation.

C-H trifluoromethylation of quinoxalin-2(1H)-ones with com. available sodium trifluoromethanesulfinate (CF3SO2Na) under visible light irradiation without any external photocatalyst was developed, provided a variety of 3-trifluoromethylquinoxalin-2(1H)-ones I [R1 = H, 6-MeO, 7-Br, etc.; R2 = H, Me, Bn, etc.] in moderate to excellent yield. Predictably, the strategy would offer an environmentally friendly and simple operational access to pharmaceutically active 3-trifluoromethylquinoxalin-2(1H)-ones without any external photocatalyst.

Asian Journal of Organic Chemistry published new progress about Green chemistry. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, Synthetic Route of 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Antczak, Christophe; Wee, Boyoung; Radu, Constantin; Bhinder, Bhavneet; Holland, Eric C.; Djaballah, Hakim published the artcile< A High-Content Assay Strategy for the Identification and Profiling of ABCG2 Modulators in Live Cells>, Name: YM-90709, the main research area is ABCG2 protein ABC transporter glioblastoma.

ABCG2 is a member of the ATP-binding cassette (ABC) family of transporters, the overexpression of which has been implicated in resistance to various chemotherapeutic agents. Though a number of cell-based assays to screen for inhibitors have been reported, they do not provide a content-rich platform to discriminate toxic and autofluorescent compounds To fill this gap, we developed a live high-content cell-based assay to identify inhibitors of ABCG2-mediated transport and, at the same time, assess their cytotoxic effect and potential optical interference. We used a pair of isogenic U87MG human glioblastoma cell lines, with one stably overexpressing the ABCG2 transporter. JC-1 (J-aggregate-forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazol carbocyanine iodide) was selected as the optimal reporter substrate for ABCG2 activity, and the resulting assay was characterized by a Z’ value of 0.50 and a signal-to-noise (S/N) ratio of 14 in a pilot screen of ∼7,000 diverse chems. The screen led to the identification of 64 unique nontoxic positives, yielding an initial hit rate of 1%, with 58 of them being confirmed activity. In addition, treatment with two selected confirmed positives suppressed the side population of U87MG-ABCG2 cells that was able to efflux the Hoechst dye as measured by flow cytometry, confirming that they constitute potent new ABCG2 transporter inhibitors. Our results demonstrate that our live cell and content-rich platform enables the rapid identification and profiling of ABCG2 modulators, and this new strategy opens the door to the discovery of compounds targeting the expression and/or trafficking of ABC transporters as an alternative to functional inhibitors that failed in the clinic.

Assay and Drug Development Technologies published new progress about Antioxidants. 163769-88-8 belongs to class quinoxaline, and the molecular formula is C22H21N3O2, Name: YM-90709.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gobec, S.; Urleb, U. published the artcile< Product class 15: quinoxalines>, Electric Literature of 5182-90-1, the main research area is review quinoxaline preparation cyclization ring transformation aromatization.

A review. Methods for preparing quinoxalines are reviewed including cyclization, ring transformation, aromatization, and substituent modification.

Science of Synthesis published new progress about Aromatization. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Electric Literature of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider