Day: October 14, 2022

do Amaral, Daniel N.; Alves, Fernando R. de Sa; Barreiro, Eliezer J.; Laufer, Stefan A.; Lima, Lidia M. published the artcile< Multi-gram preparation of 7-nitroquinoxalin-2-amine>, SDS of cas: 89898-96-4, the main research area is nitro quinoxalinamine regioselective preparation.

Methodologies to obtain quinoxaline compounds regioselectively were rarely reported in literature, thus regioselective and multi-gram methodologies to obtain these derivatives were desirable to explore the entire potential of these scaffolds for academic and/or com. application. A facile and multi-gram methodol. was described to obtain compound 7-nitroquinoxalin-2-amine I using o-phenylenediamine, a cheap and readily available reactant, as starting material in a five-step procedure in good yields and high purity without further purification such as crystallization or column chromatog.

Journal of the Brazilian Chemical Society published new progress about Quinoxalines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, SDS of cas: 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Izzo, Francesca Caterina; Vitale, Valentina; Fabbro, Chiara; Van Keulen, Henk published the artcile< Multi-analytical investigation on felt-tip pen inks: Formulation and preliminary photo-degradation study>, COA of Formula: C9H7N3O, the main research area is photodegradation felt tip pen ink archaeol.

We present a multi-anal. study on the formulation of com. felt-tip pens, introduced in the second half of the 20th century and commonly used by modern and contemporary artists. These media of both drawing and writing have not yet been fully investigated, but the degradation processes they might undergo, such as fading, are well-known and rather apparent.Twelve water-based felt-tip pens were investigated by the joint use of complementary anal. techniques, such as Thin Layer Chromatog., NMR, Fourier transformed IR spectroscopy, X-ray fluorescence spectrometry and Pyrolysis-Gas Chromatog./Mass Spectrometry.The obtained results provided crucial, preliminary data for the identification of dyes, solvents and additives present in the inks’ formulations. Numerous synthetic food coloring agents and pigments were identified, such as Acid Yellow 23, Acid Red 18, Acid Blue 9, and Pigment Blue 15. In addition, glycols, fatty acids, 2-phenoxyethanol, colophony, benzotriazole derivatives and other solvents and additives were detected in the manufactured inks.Furthermore, the effects of photo-degradation on one emblematic ink sample were studied, highlighting in particular visual and aesthetical changes due to discoloration.This study demonstrates a methodol. based upon the use of an integrated anal. approach for the characterization of com. ink-based artistic media and their viable degradation patterns, which aims to develop suitable conservation treatments to assess modern and contemporary drawings and writings.

Microchemical Journal published new progress about Archaeology. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, COA of Formula: C9H7N3O.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Kato, Akira; Fujimoto, Takeshi; Okanda, Junko published the artcile< The ring-opening reaction of benzimidazoles with 2-chloro- or 2,3-dichloro-6-nitroquinoxaline>, Computed Properties of 6272-25-9, the main research area is ring opening benzimidazole chloronitroquinoxaline; quinoxaline chloronitro ring opening benzimidazole.

1-Methylbenzimidazole underwent ring-opening reaction with 2,3-dichloro-6-nitroquinoxaline in the presence of a few drops of water in benzene under reflux to give a mixture of structural isomers, 2-[2′-(N-formyl-N-methyl)amino]anilino-3-chloro- and 2-chloro-3-[2′-(N-formyl-N-methyl)amino]anilino-6-nitroquinoxaline. Similarly, other benzimidazoles afforded ring-opening products. On the reaction of benzimidazoles with 2-chloro-6-nitroquinoxaline, the ring-opening products were obtained as single isomers.

Seikei Daigaku Kogaku Kenkyu Hokoku published new progress about Ring opening. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Computed Properties of 6272-25-9.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Tagdiwala, P. V.; Rangnekar, D. W. published the artcile< Studies on novel pigments>, Formula: C8H4ClN3O2, the main research area is nitroquinoxaline derivative pigment ink; paint pigment nitroquinoxaline derivative.

The reaction of 2-chloro-6-nitroquinoxaline(I) with hydrazine gave 1,2-bis(6-nitroquinoxalin-2-yl)hydrazine (II) [95758-19-3] in 71.4% yield for use as red pigment in printing ink and paint. Similarly the reaction of I with piperazine yielded bright yellow 1,4-bis(6-nitroquinoxalin-2-yl)piperazine (III) [95758-20-6]. Fastness of the pigments to various agents was satisfactory; however, both pigments showed poor fastness when treated with DOP plasticizer. The oil absorption value of II and III was low compared to the com. standard pigments of similar shades.

Paintindia published new progress about Castor oil Role: PRP (Properties). 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Formula: C8H4ClN3O2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gobec, S.; Urleb, U. published the artcile< Product class 15: quinoxalines>, Formula: C8H5N3O3, the main research area is review quinoxaline preparation cyclization ring transformation aromatization.

A review. Methods for preparing quinoxalines are reviewed including cyclization, ring transformation, aromatization, and substituent modification.

Science of Synthesis published new progress about Aromatization. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, Formula: C8H5N3O3.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Xingjie; Xia, Aiyou; Chen, Haoyi; Liu, Yuanhong published the artcile< General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)2: Key Roles of DMAP>, Related Products of 23088-24-6, the main research area is aryl halide zinc cyanide nickel DMAP; cyanoarene preparation; heteroaryl halide zinc cyanide nickel DMAP; cyanoheteroarene preparation; nickel cyanation catalyst; DMAP cyanation mediator.

A new and general nickel-catalyzed cyanation of hetero(aryl) chlorides using less toxic Zn(CN)2 as the cyanide source has been developed. The reaction relies on the use of inexpensive NiCl2·6H2O/dppf/Zn as the catalytic system and DMAP as the additive, allowing the cyanation to occur under mild reaction conditions (50-80 °C) with wide functional group tolerance. DMAP was found to be crucial for successful transformation, and the reaction likely proceeds via a Ni(0)/Ni(II) catalysis based on mechanistic studies. The method was also successfully extended to aryl bromides and aryl iodides.

Organic Letters published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Related Products of 23088-24-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lassagne, Frederic; Dugueperoux, Camille; Roca, Carlos; Perez, Concepcion; Martinez, Ana; Baratte, Blandine; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Erb, William; Roisnel, Thierry; Mongin, Florence published the artcile< From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)>, Quality Control of 6272-25-9, the main research area is oxazoloquinoxaline preparation glycogen synthase kinase inhibition kinetic SAR docking.

2,7-Disubstituted oxazolo[5,4-f]quinoxalines were synthesized from 6-amino-2-chloroquinoxaline in four steps (iodination at C5, substitution of the chloro group, amidation and copper-catalyzed cyclization) affording 28 to 44% overall yields. 2,8-Disubstituted oxazolo[5,4-f]quinoxaline was similarly obtained from 6-amino-3-chloroquinoxaline (39% overall yield). For the synthesis of other oxazolo[5,4-f]quinoxalines, amidation was rather performed before substitution; moreover, time-consuming purification steps were avoided between the amines and the final products (38 to 54% overall yields). Finally, a more efficient method involving merging of the last two steps in a sequential process was developed to access more derivatives (37 to 65% overall yields). Most of the oxazolo[5,4-f]quinoxalines were evaluated for their activity on a panel of protein kinases, and a few 2,8-disubstituted derivatives proved to inhibit GSK3 kinase. While experiments showed an ATP-competitive inhibition on GSK3β, structure-activity relationships allowed us to identify 2-(3-pyridyl)-8-(thiomorpholino)oxazolo[5,4-f]quinoxaline as the most potent inhibitor with an IC50 value of about 5 nM on GSK3α.

Organic & Biomolecular Chemistry published new progress about Amidation. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Quality Control of 6272-25-9.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lewis, Susan J.; Mirrlees, Margaret S.; Taylor, Peter J. published the artcile< Rationalizations among heterocyclic partition coefficients. Part 2: The azines>, Safety of 6-Quinoxalinecarbonitrile, the main research area is azine structure partition coefficient; LFER azine.

π-Values (partition substituent constants) of 246 azines are given and discussed in terms of Δπ, the difference in π-value from that expected for C6H6. It is shown that Δπ is close to zero for alkyl and most halogen groups, but for polar substituents capable of H bonding it may be as high as φ1.6. Except for peri-positions, these Δπ-values may be correlated by a set of equations specific for different types of substituent position and containing terms which sep. parameterize proton-donor and -acceptor ability. The rationale behind this treatment is justified in terms of the nature of the octanol-H2O partitioning process and the manner in which electronic effects are expected to operate, in this context and that of the individual mol. Other topics discussed include: reasons for deviations among “”irregular”” substituents; the special problems of peri-positions; multisubstitution; and some consequences of this anal. for other types of compound

Quantitative Structure-Activity Relationships published new progress about Molecular structure-property relationship, partition. 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Safety of 6-Quinoxalinecarbonitrile.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

McQuaid, Loretta A.; Smith, Edward C. R.; South, Kimberly K.; Mitch, Charles H.; Schoepp, Darryle D.; True, Rebecca A.; Calligaro, David O.; O’Malley, Patrick J.; Lodge, David; Ornstein, Paul L. published the artcile< Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones>, Quality Control of 6272-25-9, the main research area is amino acid antagonist condensed quinoxalinone; triazoloquinoxalinone amino acid antagonist; tetrazoloquinoxalinone amino acid antagonist; pyrazoloquinazolinone amino acid antagonist.

A series of substituted 1,2,4-triazolo[4,3-a]quinoxalin-4(5H)-ones I (R1 = R2 = Cl, F, R3 = H, alkyl, Ph; R1 = NO2, R2 = H, NO2, R3 = H), tetrazolo[1,5-a]quinoxalin-4(5H)-ones II (R = R2 = Cl, H, NO2; R1 = NO2, R2 = H; R1 = H, R2 = NO2), pyrazolo[1,5-c]quinazolin-5(6H)-ones III, and an imidazo[1,2-a]quinoxalin-4(5H)-one, was synthesized as potent amino acid antagonists. In general, the same heterocycles which demonstrated the best affinity for the AMPA receptor also demonstrated the best affinity for the glycine site on the NMDA receptor complex. 1-Propyl-7,8-dichloro-1,2,4-triazolo[4,3-a]quinoxalin-4(5H)-one, was found to bind with the greatest affinity to the AMPA receptor with an IC50 of 0.83 μM and antagonized 40 μM AMPA-induced depolarization in the cortical slice preparation with an IC50 of 44 μM. 7,8-Dichloro-1,2,4-triazolo[4,3-a]quinoxalin-4(5H)-one and 7,8-dichloroimidazo[1,2-a]quinoxalin-4(5H)-one possessed the best affinity for the glycine site with IC50 values of 0.63 and 1.25 μM, resp. The structure-activity relationship for the heterocyclic compounds did not directly parallel that of known quinoxalinediones (e.g. DNQX and DCQX) at the AMPA receptor nor that of the kynurenic acids at the glycine site on the NMDA receptor complex.

Journal of Medicinal Chemistry published new progress about Excitatory amino acids Role: BIOL (Biological Study). 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Quality Control of 6272-25-9.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Hoang, Thanh T.; To, Tuong A.; Cao, Vi T. T.; Nguyen, Anh T.; Nguyen, Tung T.; Phan, Nam T. S. published the artcile< Direct oxidative C-H amination of quinoxalinones under copper-organic framework catalysis>, Related Products of 89898-96-4, the main research area is copper organic framework catalyst preparation green chem; quinoxalinone amine carbon hydrogen activation amination; aminoquinoxalinone preparation.

A copper-organic framework Cu-CPO-27 was synthesized, and utilized as a recyclable heterogeneous catalyst for the direct C-H amination of quinoxalin-2(1H)-ones with amines to produce 3-aminoquinoxalin-2(1H)-ones, e.g., I. High yields were achieved in the presence of mol. oxygen as the oxidant. This framework was more catalytically active than a number of MOF-based catalysts. The Cu-CPO-27 also displayed higher performance than CuFe2O4 nanoparticles. The copper-organic framework catalyst could be reutilized in the synthesis of 3-aminoquinoxalin-2(1H)-ones via the direct C-H amination reaction without a remarkable deterioration in catalytic performance. This is the first heterogeneous catalytic protocol to generate 3-aminoquinoxalin-2(1H)-ones.

Catalysis Communications published new progress about Amination. 89898-96-4 belongs to class quinoxaline, and the molecular formula is C8H5N3O3, Related Products of 89898-96-4.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider