Month: October 2022

Rangnekar, D. W.; Tagdiwala, P. V. published the artcile< Synthesis of 6-acetamido-2-substituted quinoxaline derivatives and their use as fluorescent whiteners for polyester fibers>, Application In Synthesis of 6272-25-9, the main research area is quinoxaline acetamido dye polyester; acetamidoquinoxaline fluorescent brightener; polyester disperse dye acetamidoquinoxaline.

6-Nitro-2-chloroquinoxaline  [6272-25-9] was condensed with amines, alcs. and phenols to give 6-nitro-2-substituted quinoxalines. The nitro compounds were reduced to the corresponding amino compounds and then acetylated to yield 6-acetamido-2-substituted quinoxalines. 6-Nitro-2-substituted amino quinoxalines and 6-acetamido-2-substituted quinoxalines were evaluated as disperse dyes and fluorescent brighteners, resp., on polyester fibers.

Dyes and Pigments published new progress about Disperse dyeing. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, Application In Synthesis of 6272-25-9.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Shahin, Mai I.; Abou El Ella, Dalal A.; Ismail, Nasser S. M.; Abouzid, Khaled A. M. published the artcile< Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold>, COA of Formula: C8H4ClN3O2, the main research area is arylaminoquinoxalinone arylaminoquinoxaline ureidoarylaminoquinoxaline preparation VEGFR2 inhibitor; structure arylaminoquinoxalinone arylaminoquinoxaline ureidoarylaminoquinoxaline inhibition VEGFR2 kinase; mol docking arylaminoquinoxalinone arylaminoquinoxaline ATP binding site VEGFR2; calculated lipophilicity solubility absorption CYP 2D6 inhibition arylaminoquinoxalinone arylaminoquinoxaline; Docking study; Kinase; Quinoxaline; Type-II; VEGFR-2.

Arylaminoquinoxalinones I [R = HO; R1 = 4-MeOC6H4NH; R2 = R3NHC(:X)NH, 4-R4C6H4SO2NH, 2-HO2CC6H4CONH, MeCONH; R3 = Ph, 3-ClC6H4, 3-MeC6H4, cyclohexyl; R4 = H, Me; X = O, S], arylaminoquinoxalines I [R = H; R1 = 4-R5C6H4NH; R2 = R3NHC(:X)NH, 4-R4C6H4SO2NH, MeCONH; R3 = Ph, 3-MeC6H4, cyclohexyl; R4 = H, Me; R5 = MeO, Cl; X = O, S] and ureidoarylaminoquinoxalines I [R = H; R1 = 4-(3-R6C6H4NHCONH)C6H4NH; R2 = O2N; R6 = H, Cl] were prepared as ATP-competitive VEGFR-2 inhibitors for potential use as antitumor agents. I (R = HO; R1 = 4-MeOC6H4; R2 = PhNHCONH) was the most effective VEGFR-2 inhibitor of the compounds prepared at a concentration of 10 μM. Mol. docking calculations were performed to rationalize the selectivities of quinoxalines for VEGFR-2; calculated physicochem. properties, absorption, and probabilities of CYP 2D6 inhibition were determined for the compounds

Bioorganic Chemistry published new progress about Biological permeation. 6272-25-9 belongs to class quinoxaline, and the molecular formula is C8H4ClN3O2, COA of Formula: C8H4ClN3O2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Minisci, Francesco; Citterio, Attilio; Vismara, Elena; Giordano, Claudio published the artcile< Polar effects in free-radical reactions. New synthetic developments in the functionalization of heteroaromatic bases by nucleophilic radicals>, Related Products of 5182-90-1, the main research area is lepidine alc nucleophilic radical substitution; hydroxylaminium salt titanium substitution catalyst; hydroxyalkyllepidine; substitution catalyst benzoyl peroxide hydrogen; carbamoylation quinoline acridine pyrazine benzothiazole; heteroaromatic base carbamoylation peroxide catalyst; dioxane hydrofuran lepidine radical substitution.

Direct substitution of protonated heteroaromatic bases by nucleophilic carbon-centered radicals involved use of the redox system N+H3OH/Ti(III) in several solvents, use of benzoyl peroxide in alcs., and carbamoylation by HCONH2 and H2O2 in the presence of catalytic Fe(II). Thus lepidine I (R = H) in MeOH gave 98% I (R = CH2OH) in the presence of benzoyl peroxide. These systems gave hitherto unobtainable substitution products and reactions of industrial interest. Polar effects determine reactivity, selectivity and synthetic applications; in particular the role of the strongly nucleophilic intermediate radicals of pyridinyl type in the rearomatization step is emphasized.

Tetrahedron published new progress about Carbamoylation. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Related Products of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Niculescu, A. B.; Le-Niculescu, H.; Roseberry, K.; Wang, S.; Hart, J.; Kaur, A.; Robertson, H.; Jones, T.; Strasburger, A.; Williams, A.; Kurian, S. M.; Lamb, B.; Shekhar, A.; Lahiri, D. K.; Saykin, A. J. published the artcile< Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs>, COA of Formula: C22H21N3O2, the main research area is Alzheimer disease blood biomarker memory pharmacogenomics.

We carried out longitudinal within-subject studies in male and female psychiatric patients to discover blood gene expression biomarkers that track short term memory as measured by the retention measure in the Hopkins Verbal Learning Test. These biomarkers were subsequently prioritized with a convergent functional genomics approach using previous evidence in the field implicating them in AD. The best overall evidence was for a series of new, as well as some previously known genes, which are now newly shown to have functional evidence in humans as blood biomarkers: RAB7A, NPC2, TGFB1, GAP43, ARSB, PER1, GUSB, and MAPT. Addnl. top blood biomarkers include GSK3B, PTGS2, APOE, BACE1, PSEN1, and TREM2, well known genes implicated in AD by previous brain and genetic studies, in humans and animal models, which serve as reassuring de facto pos. controls for our whole-genome gene expression discovery approach. A majority of top biomarkers also have evidence for involvement in other psychiatric disorders, particularly stress, providing a mol. basis for clin. co-morbidity and for stress as an early precipitant/risk factor. Some of them are modulated by existing drugs, such as antidepressants, lithium and omega-3 fatty acids. Other drug and nutraceutical leads were identified through bioinformatic drug repurposing analyses (such as pioglitazone, levonorgestrel, salsolidine, ginkgolide A, and icariin).

Molecular Psychiatry published new progress about Alzheimer disease. 163769-88-8 belongs to class quinoxaline, and the molecular formula is C22H21N3O2, COA of Formula: C22H21N3O2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Otsuka, H.; Shoji, J. published the artcile< Structure of triostin C>, Reference of 5182-90-1, the main research area is .

Triostin antibiotics from a streptomyces related to Streptomyces aureus gave a mixture of components C and A. The mixture (600 mg.) chromatographed on silica gel and eluted with CHCl3-MeOH solutions containing increased concentrations of MeOH from 0-3% and with control by observation of optical densities at 243 mμ, the antibiotic fractions examined by thin-layer chromatography on Al2O3 (solvent, lower layer of 3:1:3 EtOAcCl2CHCHCl2-H2O) and the concentrates containing component C crystallized from CHCl3-MeOH gave 280 mg. triostin C (I), decomposing above 260°, [α]24D -143.9 ± 2° (c 1.121, CHCl3), mol. weight 1125 (Barger-Niederl, CHCl3), 1120 (osmometry, CHCl3). I hydrolyzed 20 hrs. in 6N HCl at 105° and the hydrolysate examined by 2-dimensional paper chromatography gave 4 ninhydrin pos. substances, Rf in 4:1:2 BuOH-AcOH-H2O (and H2O-saturated PhOH): N,N’-dimethylcycstine (II) 0.18 (0.84); alanine (III) 0.36 (0.56); N,γ-dimethylalloisoleucine (IV) 0.74 (0.92); serine (V) 0.26 (0.37). When developed with a collidine-containing MeOH ninhydrin solution (CA 59, 9550a) the spots were brownish-purple, purple, brownish-purple, and grayish-purple. II and IV gave red spots with p-O2NC6H4COCl-C5H5N, indicative of N-alkyl amino acids, and II gave also a red spot with Na2Fe(CN)5NO.2H2O-NaCN. The total acid hydrolysate from 500 mg. I concentrated and extracted with H2O, chromatographed on cellulose and eluted with 4:1:2 BuOH-AcOH-H2O gave in order IV, III, V, II. Similar chromatographic separation on Dowex 50 W × 4 and elution with 0.2M C5H5N-HCO2H (pH 2.80) gave II, V, IV and III in order with partial overlap. The individual acids were isolated by decolorization of the fractions with C and recrystallization to give V, m. 220-5° (decomposition) (H2O-EtOH), [α]24D -14.6 ± 2° (c 0.994, 1.0N HCl); L-III, m. 280-2° (decomposition) (H2O-EtOH), [α]23D 12.1 ± 4° (c 0.626, 1.0N HCl); II, gel-like and difficult to purify, m. 175-82° (decomposition), [α]26D 22.7 ± 2° (c 1.049, 1.0N HCl), [α]25D 34.0 ± 2° (c 1.022, 1.0N HCl), ir spectrum identical with that of synthetic compound, m. 215-17° (decomposition), [α]25D 58.1 ± 2° (c 1.00, 1.0N HCl); L-IV, m. 300°, [α]25.5D 28.4 ± 2° (c 0.937, H2O), 41.9 ± 2° (c 1.049, 5N HCl). II (10 mg.) in 2 ml. H2O stirred 2 hrs. at 45° with 300 mg. Raney Ni and the combined filtrate and H2O-washings examined by paper chromatography on 4:1:2 BuOH-AcOH-H2O, H2O-saturated iso-Pr CH2OH, H2O-saturated Me2CCH2OH, H2O-saturated PhCH2OH, and H2O-saturated PhOH showed Rf values of 0.40, 0.22, 0.06, 0.15, and 0.84 resp., identical with those of synthetic DL-MeCH(NHMe)CO2H. I (500 mg.) partially hydrolyzed in concentrated HCl at 37° 2 days and extracted with EtOAc, the aqueous layer examined for amino acids and the decolorized extract chromatographed on paper with BuOH saturated with 3% aqueous NH4OH as solvent gave quinoxaline-2-carboxylic acid (VI), m. 210-11° (decomposition), ir spectrum identical with that of synthetic VI. I (4.100 mg.) in 0.5 ml. 6N HCl heated 72 hrs. at 105° in an evacuated sealed tube and the hydrolysate submitted to amino acid analysis showed the presence per mole I of 1.48 moles V, 2.02 moles III, 2.16 moles half II, and 2.14 moles IV. A larger amount of V was obtained under milder conditions of hydrolysis. I (2.160 mg.) heated 20 hrs. in 0.3 ml. 5N NaOH at 105° and adjusted with Dowex 50 W (H type) to pH 8.2, acidified with dilute HCl and analyzed gave 0.083 moles V, 1.98 moles III, 1.67 moles IV, and 0.74 mole NH3 per mole I. Extraction of a portion of the hydrolysate with EtOAc gave VI. I (100 mg.) in 6 ml. 90% MeOH containing 0.1N Na0H stirred 2 hrs. at 25° and diluted with 40 ml. H2O, adjusted to pH 2.0 and extracted with EtOAc, transferred into 15 ml. 5% NaHCO3 and reextracted with EtOAc at pH 2.0, the washed extract concentrated and diluted with C6H14 gave 93 mg. alkali-treated triostin C (VII), m. 159-62°, mol. weight 1300 (osmometry, CHCl3), 1000-1300 (Barger-Akiya, Me2CO), pKa 5.7, giving only 0.065 mole V, 1.98 moles III, 2.04 moles half II, 2.06 moles IV, and 2.32 moles NH3 in acid hydrolysis, suggesting the formation of a dehydroalanine derivative by β-elimination reaction on the O-substituted serine residue caused by alkali treatment. VII (15 mg.) heated 3 hrs. at 100° in 0.5 ml. 3N HCl gave 1.8 mole pyruvic acid as determined as its 2,4-dinitrophenylhydrazone, m. 218-20° (MeOH-H2O). VII in 1:1 dioxane-H2O boiled at pH 2.0 released quinoxaline-2-carboxamide, m. 204.5-5.5°. Dakin-West degradation of VII showed that IV was the C-terminal amino acid. VII dinitrophenylated and submitted to acid hydrolysis failed to give dinitrophenylated amino acids, indicating that VI was attached to N-terminal amino acid. Accordingly a lactone linkage was presumed to exist in I. CrO3 oxidation of I did not destroy V, indicating that the OH group of V was involved in the lactone linkage. I (100 mg.) in 2 ml. HCO2H kept 16 hrs. at 0° with 20 ml. performic acid reagent according to Thompson (CA 49, 4748a) and the mixture diluted with 80 ml. H2O, freeze-dried and the residue extracted with MeOH, precipitated with Et2O and the 80 mg. hygroscopic powder analyzed showed the presence of III, IV, V, and N-methylcysteic acid (VIII). I (100 mg.) in 15 ml. 4:1 dioxane-H2O stirred 4.5 hrs. with 1.0 g. Raney Ni W-2 at 80-90° and the filtered solution and washings evaporated, the residue extracted and the extract diluted with C6H14 gave 68 mg. dethiotriostin C (IX), m. 183-6° (decomposition), mol. weight 940, 1000-1300, hydrolyzed to give 1.48 moles V, 1.90 moles III, 2.00 moles N-methylalanine (X), and 1.99 moles IV. I gave no reaction with Na2Fe(CN)5NO-NaCN reagent but a pos. reaction for the disulfide bond was obtained following treatment with cold, dilute NaOH with opening of the lactone ring and increasing solubility The mol. weight determination of IX confirmed a proposed partial formulation and it remained to elucidate the amino acid sequence between IV and V. IX was partially hydrolyzed by concentrated HCl at 37° 2 days and the hydrolysate extracted with BuOH to sep. chromophore and simple peptide fragments. The chromophore peptides, characterized by uv absorption, were separated on a 2-dimensional paper chromatogram in BuOH saturated with aqueous NH4OH followed by 1.5M phosphate buffer, pH 5.0, giving N-(quinoxaline-2-carboxyl)serine and N-(quinoxaline-2-carboxyl)serylalanine, N-(quinoxaline-2-carboxyl)-O-(N,γ-dimethylalloisoleucyl)serine and N-(quinoxaline-2-carboxyl)-O-(N,γ-dimethylalloisoleucyl)serylalanine. As simple peptide fragments, serylalanine and serylalanyl-N-methylalanyl-N,γ-dimethylalloisoleucine were separated by paper chromatography in BuOH-AcOH-H2O followed by H2O-saturated phenol. Similar acid hydrolysis with I gave another 2 peptide fragments consisting of V, III and N,N’-dimethylcystine. It was concluded that I has the proposed structure. There are 2 series of quinoxaline antibiotics; one has a dithiane ring as in echinomycin, and the other contains an N,N’-dimethyl residue. Each series involves several antibiotics differing only in their N-methylamino acid constituents.

Tetrahedron published new progress about 5182-90-1. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Reference of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Landquist, Justus K. published the artcile< Quinoxaline N-oxides. I. The oxidation of quinoxaline and its Bz-substituted derivatives>, Recommanded Product: 6-Quinoxalinecarbonitrile, the main research area is .

Quinoxaline (I) and its Bz-substituted-alkyl, alkoxy, halo, and acylamino derivatives are oxidized to 1- and 1,4-dioxides by organic peroxy acids. Resistance to N-oxidation is encountered in 5- and 8-substituted I. Reduction of 2,3-(O2N)2C6H3OEt with H and Raney Ni gave 3,1,2-EtOC6H3(NH2)2, oil (picrate, m. 210-12°). 2,4-Br(O2N)C6H3Me nitrated with HNO3 and H2SO4 at 40-5° gave 2,4,5-Br(O2N)2C6H2Me, m. 94-5°, which, treated with NH3 in alc. 5 h. at 120° and then reduced with Zn dust and NaOH in EtOH, yielded the 4,5-(H2N)2 analog, m. 140-1°. The following general procedure for preparation of I derivatives was used: (CHO.NaHSO3)2, an ο-phenylenediamine, and H2O were stirred 3 h. at 60°, then made alk. with KOH, and the I derivative was filtered off. The following derivatives were prepared (substituent, m.p., m.p. of 1-oxide, m.p. of 1,4-dioxide): 5-Me, 20-1°, b15, 120°, 131-2°, 192-4°; 5-EtO, 63-4°, b18 165-6°, 114-16°, -; 5-Cl (II), 60-2°, 177-9°, -; 6-iodo, 114-15°, -, -; 6-NC (III), 176-8°, -, -; 6,7-Me2, 100-1°, -, 220°; 6,7-benzo, 125-6°, -, -; 6,7-ClMe (IV), 120-2°, 166-8°, 227°; 6,7-BrMe (V), 127-8°, 167-8°, 222-4°; 6,7-Cl2 (VI), 210°, -, 206-8°; 5,8-Cl2 (VII), 205-7°, -, -; 6-Br (VIII)(prepared by the Sandmeyer reaction from the 6-NH2 compound), 48-9°, b18 146-9°, -, 223-5°; 6-AcNH (prepared from the 6-NH2 compound with Ac2O), 196.5°, -, 245-7°; 5-AcNH, -, 175-8°, 230-2° (insufficient for anal.). The following N-oxides were also prepared (substituent, m.p. 1-oxide, m.p. 1,4-dioxide): 6-Me (IX), -, 218-19°; 5,6-benzo, 158-9°, 215-16°; 5,6:7,8-dibenzo, 243-4°, -; 5-MeO, -, 222°; 6-MeO, -, 227-8°; 6-EtO, -, 192-4°; 5,6-(MeO)2, 138-40°, 220-2°; 6,7-(MeO)2, -, 264-5°; 2-Cl, 150-2°, -; 6-Cl (X), 151-2°, 211-12°. I is oxidized with equimolar AcO2H to quinoxaline 1-oxide, m. 122-3° (XI) while excess peroxy acid yields quinoxaline 1,4-dioxide, m. 241-3° (XII). Simultaneous with N-oxide formation there were obtained 2,3-dihydroxyquinoxalines which are listed below: (substituent, % yield, m.p.): IX, 1, 112°; II, 30, 142-3°; X, 15-30, 144°; VIII, 28, 132°; VII, 65, 160-1°; VI, 43, 170-70.5°; IV, 10, 172-3°; V, 12-6, 160-1°; III, 50, -; 6-O2N, 60, 150°. XI and MeI in MeCN set aside in the dark 36 h., precipitated 1-methylquinoxalinium iodide 4-oxide, m. 188-9°. XI was added cautiously to POCl3, and the mixture boiled 15 min. after the reaction subsided, poured on ice, made alk. with KOH, extracted with Et2O, and concentrated to yield 2-chloroquinoxaline, m. 46-8°. Under similar conditions XII yielded 2,3-dichloroquinoxaline; 5-methylquinoxaline 1-oxide gave 2-chloro-5-methylquinoxaline, m. 95°; and 5,6-benzoquinoxaline 1-oxide yielded 2-chloro-5,6-benzoquinoxaline, m. 120.5°. 2-C10H7NHCH2CO2Et dissolved treated in EtOH with PhN2Cl yielded 1,2-Ph2NC10H6NHCH2CO2Et, m. 135-6°, hydrogenated with Raney Ni at 60° and 50 atm. to 1,2,3,4-tetrahydro-2-oxo-7,8-benzoquinoxaline (XIII), m. 197-8°. XIII with alk. H2O2 gave 2-hydroxy-7,8-benzoquinoxaline, isolated as the hydrate, m. 275-5.5°, which was converted with POCl3 into 2-chloro-7,8-benzoquinoxaline, m. 128-9°. N-(6-nitro-o-tolyl)glycine in EtOH hydrogenated over Raney Ni at 60° and 60 atm. yielded 1,2,3,4-tetrahydro-5-methyl-2-oxoquinoxaline, m. 177-80°, readily oxidized to 2-hydroxy-5-methylquinoxaline, m. 282-3°. 2-Chloro-7,8-benzoquinoxaline and piperidine refluxed 1.5 h. gave 2-piperidino-7,8-benzoquinoxaline, m. 101.5-2.5°. 2-Piperidino-5,6-benzoquinoxaline, m. 124-5°, was similarly prepared Cl slowly passed 1 h. into 5,6-benzoquinoxaline in glacial HOAc, and the solution filtered and diluted with H2O yielded, on purification, dichloro-5,6-benzoquinoxaline, m. 187-8°. Methylation of 2,3-dihydroxy-6-nitroquinoxaline with Me2SO4 gave 3-hydroxy-1-methyl-6(or 7)-nitro-2(1H)-quinoxalinone, m. 344°. 6(or 7)-Cyano-3-hydroxy-1-methyl-2(1H)-quinoxalinone, m. 353-4°, is similarly prepared

Journal of the Chemical Society published new progress about Oxidation. 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Recommanded Product: 6-Quinoxalinecarbonitrile.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Huang, Yao; Chen, Tieqiao; Li, Qiang; Zhou, Yongbo; Yin, Shuang-Feng published the artcile< Copper catalysed direct amidation of methyl groups with N-H bonds>, Reference of 5182-90-1, the main research area is methyl group amidation copper catalyst.

An efficient copper catalyzed direct aerobic oxidative amidation of Me groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.

Organic & Biomolecular Chemistry published new progress about Amidation. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Reference of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Tymoshenko, D. O. published the artcile< Quinoxalines (update 2012)>, Electric Literature of 5182-90-1, the main research area is review quinoxaline preparation.

A review of the synthetic approaches to quinoxaline and related systems.

Science of Synthesis, Knowledge Updates published new progress about Organic synthesis. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, Electric Literature of 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lewis, Susan J.; Mirrlees, Margaret S.; Taylor, Peter J. published the artcile< Rationalizations among heterocyclic partition coefficients. Part 2: The azines>, SDS of cas: 5182-90-1, the main research area is azine structure partition coefficient; LFER azine.

π-Values (partition substituent constants) of 246 azines are given and discussed in terms of Δπ, the difference in π-value from that expected for C6H6. It is shown that Δπ is close to zero for alkyl and most halogen groups, but for polar substituents capable of H bonding it may be as high as φ1.6. Except for peri-positions, these Δπ-values may be correlated by a set of equations specific for different types of substituent position and containing terms which sep. parameterize proton-donor and -acceptor ability. The rationale behind this treatment is justified in terms of the nature of the octanol-H2O partitioning process and the manner in which electronic effects are expected to operate, in this context and that of the individual mol. Other topics discussed include: reasons for deviations among “”irregular”” substituents; the special problems of peri-positions; multisubstitution; and some consequences of this anal. for other types of compound

Quantitative Structure-Activity Relationships published new progress about Molecular structure-property relationship, partition. 5182-90-1 belongs to class quinoxaline, and the molecular formula is C9H7N3O, SDS of cas: 5182-90-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Climent, M. J.; Corma, A.; Hernandez, J. C.; Hungria, A. B.; Iborra, S.; Martinez-Silvestre, S. published the artcile< Biomass into chemicals: One-pot two- and three-step synthesis of quinoxalines from biomass-derived glycols and 1,2-dinitrobenzene derivatives using supported gold nanoparticles as catalysts>, Recommanded Product: 6-Quinoxalinecarbonitrile, the main research area is vicinal diol phenylenediamine gold nanoparticle oxidation cyclocondensation catalyst; dinitrobenzene vicinal diol gold nanoparticle reduction oxidation cyclocondensation catalyst; quinoxaline preparation.

An efficient and selective one-pot two-step method, for the synthesis of quinoxalines by oxidative coupling of vicinal diols with 1,2-phenylenediamine derivatives, has been developed by using gold nanoparticles supported on nanoparticulated ceria (Au/CeO2) or hydrotalcite (Au/HT) as catalysts and air as oxidant, in the absence of any homogeneous base. Reaction kinetics shows that the reaction controlling step is the oxidation of the diol to α-hydroxycarbonyl compound Furthermore, a one-pot three-step synthesis of 2-methylquinoxaline starting from 1,2-dinitrobenzene and 1,2-propanediol has been successfully carried out with 98% conversion and 83% global yield to the final product.

Journal of Catalysis published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 23088-24-6 belongs to class quinoxaline, and the molecular formula is C9H5N3, Recommanded Product: 6-Quinoxalinecarbonitrile.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider