On January 28, 2021, Pan, Shiow-Lin; Yang, Chia-Ron; Huang, Han-Li; Tu, Huang-Ju; Liou, Jing-Ping; Teng, Che-Ming published a patent.Electric Literature of 62163-09-1 The title of the patent was Preparation of hydroxamic acid compounds as histone deacetylase 6 inhibitors and method for treating neuropathic pain. And the patent contained the following:
Disclosed herein are hydroxamic acid compounds of formula I. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6. Compounds of formula I wherein A is absent and CR1R2; E is absent and CR3R4; W is bicyclic aryl and bicyclic heteroaryl; X is CR5R6, O, S and NH and derivatives; Y is arylene and heteroarylene; Z is a bond, methylene and ethylene; R1, R2, R3 and R4 are independently H, halo, CN, amino, OH, etc.; R5 and R6 are independently H, (un)substituted C1-5 alkyl, (un)substituted C1-5 alkenyl, (un)substituted aryl, etc.; are claimed. Example compound II was prepared by reductive amination of Me 4-formylbenzoate with 3-quinolinamine followed by amidation with hydroxylamine hydrochloride. The invention compounds were evaluated for their HDAC6 inhibitory activity.y. From the assay, it was determined that compound II exhibited IC50 values of 19.11 nM and 0.78μM towards HDAC6 and HDAC1, resp. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Electric Literature of 62163-09-1
The Article related to hydroxamic acid preparation hdac6 inhibitor treatment neuropathic pain, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Electric Literature of 62163-09-1
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider