Day: November 8, 2022

Kinlin, Thomas E.; Muralidhara, Ranya; Pittet, Alan O.; Sanderson, Anne; Walradt, John P. published an article in 1972, the title of the article was Volatile components of roasted filberts.COA of Formula: C8H10N2 And the article contains the following content:

Roasted filbert volatiles were isolated using the following techniques: steam distillation followed by solvent extraction; condensation of volatiles given off during steam distillation; and mol. distillation followed by fractionation using preparative gas chromatog. Extracts and fractions were analyzed using open tubular columns. 187 compounds are reported for the 1st time from roasted filbert volatiles including alkyl, alkenyl, oxygenated, and alicyclic pyrazines; pyrroles; pyridines; thiols, thiazoles, thiophenes, and sulfides; furans; phenols; acids; lactones; esters; terpenes; aromatic aldehydes, alkanals, 2-alkenals, and 2,4-alkadienals; aliphatic and olefinic alcohols and ketones; and aliphatic and aromatic hydrocarbons. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).COA of Formula: C8H10N2

The Article related to filbert roasted volatiles, Foods: Animal Origin and other aspects.COA of Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Mussinan, Cynthia J.; Wilson, Richard A.; Katz, Ira published an article in 1973, the title of the article was Isolation and identification of pyrazines present in pressure-cooked beef.Safety of 5,6,7,8-Tetrahydroquinoxaline And the article contains the following content:

Flavor concentrations were isolated from beef cooked superatmospherically at 162.7.degree. by simultaneous steam distillation and continuous solvent extraction Separation and identification were accomplished by gas chromatog. and coupled gc-mass spectrometry. Mass spectral identifications were confirmed by IE values. A total of 33 pyrazines were identified. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Safety of 5,6,7,8-Tetrahydroquinoxaline

The Article related to pyrazine compound cooked beef, flavor cone cooked beef, Foods: Animal Origin and other aspects.Safety of 5,6,7,8-Tetrahydroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Folkes, D. J.; Gramshaw, J. W. published an article in 1977, the title of the article was Volatile constituents of white bread crust.Product Details of 34413-35-9 And the article contains the following content:

A total of 190 volatile components were identified in essences prepared from white bread crust (in 20 cases the identification is provisional); of these compounds 97 have not previously been reported as constituents of white bread. A limited number only, of the compounds reported, may be partially responsible for the crusty notes present in bread aroma. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Product Details of 34413-35-9

The Article related to bread crust odor, Foods: Vegetable Origin and other aspects.Product Details of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Vitzthum, O. G.; Werkhoff, P.; Hubert, P. published an article in 1975, the title of the article was Volatile components of roasted cocoa. Basic fraction.Category: quinoxaline And the article contains the following content:

Roasted cocoa volatiles were isolated using the following technique:extraction with supercritical CO2 under pressure followed by atm. steam distillation; adsorption on Porapak Q and subsequent extraction with purified diethylether; separation of the organic phase into basic and neutral fractions. Identification of basic cocoa aroma constituents was accomplished by mass spectrometry in combination with a 200m × 0.31 mm i.d. glass capillary column. For the 1st time 59 compounds are reported in roasted cocoa including alkyl-, alkenyl, acyl-, furyl- and alicyclic pyrazines, pyridines, quinoxalines, oxazoles, quinoline [91-22-5] and methyl o-aminobenzoate [134-20-3]. The CO2-extraction process described is generally applicable to studies on volatile aroma constituents in food odor research. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Category: quinoxaline

The Article related to cocoa volatile compound, flavor compound cocoa, Foods: Vegetable Origin and other aspects.Category: quinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Malone, J. P.; McGimpsey, H. C. published an article in 1977, the title of the article was Fungicidal control of foliar diseases of barley in Northern Ireland.Formula: C8H10N2 And the article contains the following content:

Trials were carried out during 1971-74 in which 5 barley cultivars and 9 fungicides were employed for the control of mildew (Erysiphe graminis) and leaf blotch (Rhynchosporium secalis). The highest level of mildew was recorded in 1973 and of leaf blotch in 1972. All of the treatments used in 1973 reduced the level of mildew and several of them the level of leaf senescence, the best result being obtained with tridemorph [24602-86-6]. The treatment also increased grain yield and thousand (M) grain weight (benomyl [17804-35-2] and chlorquinox [9004-32-4] by ∼10%) but the differences between treatments were not significant. When the level of mildew was low, it was reduced by ethirimol [23947-60-6] seed treatment in 1971 and by all the treatments in 1974, but this did not significantly affect yield or M weight In 1971 and 1972 benomyl reduced the level of leaf blotch and in 1972 the level of leaf senescence. It also increased M weight in 1971, and both yield and M weight in 1972. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to barley erysiphe rhynchosporium fungicide, Agrochemicals: Microbial and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On April 30, 2002, Adams, T. B.; Doull, J.; Feron, V. J.; Goodman, J. I.; Marnett, L. J.; Munro, I. C.; Newberne, P. M.; Portoghese, P. S.; Smith, R. L.; Waddell, W. J.; Wagner, B. M. published an article.Formula: C8H10N2 The title of the article was The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. And the article contained the following:

A review. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicol. Flavor ingredients are evaluated individually taking into account the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of pyrazine derivatives as flavoring ingredients is evaluated. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Formula: C8H10N2

The Article related to review pyrazine flavor gras, Food and Feed Chemistry: Reviews and other aspects.Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On November 30, 1983, Lewis, Susan J.; Mirrlees, Margaret S.; Taylor, Peter J. published an article.Synthetic Route of 62163-09-1 The title of the article was Rationalizations among heterocyclic partition coefficients. Part 2: The azines. And the article contained the following:

π-Values (partition substituent constants) of 246 azines are given and discussed in terms of Δπ, the difference in π-value from that expected for C6H6. It is shown that Δπ is close to zero for alkyl and most halogen groups, but for polar substituents capable of H bonding it may be as high as φ1.6. Except for peri-positions, these Δπ-values may be correlated by a set of equations specific for different types of substituent position and containing terms which sep. parameterize proton-donor and -acceptor ability. The rationale behind this treatment is justified in terms of the nature of the octanol-H2O partitioning process and the manner in which electronic effects are expected to operate, in this context and that of the individual mol. Other topics discussed include: reasons for deviations among “irregular” substituents; the special problems of peri-positions; multisubstitution; and some consequences of this anal. for other types of compound The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Synthetic Route of 62163-09-1

The Article related to azine structure partition coefficient, lfer azine, Pharmacology: Structure-Activity and other aspects.Synthetic Route of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On February 8, 2018, Lee, Hsueh-Yun; Nepali, Kunal; Huang, Fang-I.; Chang, Chih-Yi; Lai, Mei-Jung; Li, Yu-Hsuan; Huang, Hsiang-Ling; Yang, Chia-Ron; Liou, Jing-Ping published an article.Computed Properties of 62163-09-1 The title of the article was (N-Hydroxycarbonylbenzylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo. And the article contained the following:

A series of bicyclic arylamino/heteroarylamino hydroxamic acids (7-31) have been examined as novel histone deacetylase 6 (HDAC6) inhibitors. One compound (13, N-hydroxy-4-((quinolin-8-ylamino)methyl)benzamide) exhibits remarkable inhibitory activity of HDAC6 with an IC50 value of 0.29 nM, which is 4000-43,000 times more selective over other HDAC isoforms. Compound 13 was shown to have antiproliferative activity against human multiple myeloma RPMI 8226, U266, and NCI-H929 cells with no effect on normal bone marrow cells. Compound 13, as a single drug, suppresses the growth of tumors by a %TGI factor of 60.4% in human multiple myeloma RPMI 8226 xenograft models and, in combination with bortezomib, shows significant in vivo antitumor activity (%TGI = 86.2%). Compound 13 also demonstrates good human hepatocytic stability and high permeability, without any effect on mutagenicity and cytotoxicity. Thus, compound 13 is a potent HDAC6 inhibitor that could be developed for the treatment of multiple myeloma in the future. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Computed Properties of 62163-09-1

The Article related to hydroxycarbonylbenzylaminoquinoline preparation histone deacetylase hdac6 inhibitor antitumor myeloma, Pharmacology: Structure-Activity and other aspects.Computed Properties of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Rychen, Guido; Aquilina, Gabriele; Azimonti, Giovanna; Bampidis, Vasileios; Bastos, Maria de Lourdes; Bories, Georges; Cocconcelli, Pier Sandro; Flachowsky, Gerhard; Gropp, Juergen; Kolar, Boris; Kouba, Maryline; Lopez Puente, Secundino; Lopez-Alonso, Marta; Mantovani, Alberto; Mayo, Baltasar; Ramos, Fernando; Saarela, Maria; Villa, Roberto Edoardo; Wallace, Robert John; Wester, Pieter; Brantom, Paul; Dusemund, Birgit; Hogstrand, Christer; Van Beelen, Patrick; Westendorf, Johannes; Gregoretti, Lucilla; Manini, Paola; Chesson, Andrew; EFSA Panel on Additives and Products or Substances used in Animal Feed published an article in 2017, the title of the article was Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species.Electric Literature of 34413-35-9 And the article contains the following content:

A review. Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 22 compounds belonging to chem. group 24 (pyrazine derivatives). They are currently authorised as flavours in food. The FEEDAP Panel concludes that: 2,3-diethylpyrazine [14.005], 2-ethyl-3-methylpyrazine [14.006], 5,6,7,8-tetrahydroquinoxaline [14.015], 2,3,5,6-tetramethylpyrazine [14.018], 2,3,5-trimethylpyrazine [14.019], 2,5-dimethylpyrazine [14.020], 2,6-dimethylpyrazine [14.021], 2-ethylpyrazine [14.022], 2-ethyl-3,5-dimethylpyrazine [14.024], 2,5 or 6-methoxy-3-methylpyrazine [14.025], 2-methylpyrazine [14.027], acetylpyrazine [14.032], 6,7-dihydro-5-methyl-5H-cyclopenta(b)pyrazine [14.037], 2-isobutyl-3-methoxypyrazine [14.043], 2-acetyl-3-ethylpyrazine [14.049], 2,3-dimethylpyrazine [14.050], 2,3-diethyl-5-methylpyrazine [14.056], 2-(sec-butyl)-3-methoxypyrazine [14.062], 3,(5- or 6-)-dimethyl-2-ethylpyrazine [14.100], 2-ethyl-3-methoxypyrazine [14.112] and 2-methoxy-3-methylpyrazine [14.126] are safe at the proposed maximum dose level (0.5 mg/kg complete feed) as feed for cattle, salmonids and non-food-producing animals, and at the proposed normal use level of 0.1 mg/kg complete feed for pigs and poultry; 5-methylquinoxaline [14.028] are safe only at concentrations below the proposed use levels (0.08 mg/kg complete feed for cattle, salmonids and non-food-producing animals, and 0.05 mg/kg complete feed for pigs and poultry). No safety concern would arise for the consumer from the use of these compounds up to the highest proposed level in feeds. Hazards for skin and eye contact, and respiratory exposure are recognized for the majority of the compounds under application. Most are classified as irritating to the respiratory system. The proposed maximum use levels in feed are unlikely to have detrimental effects on the terrestrial and fresh water compartments. Because all the compounds under assessment are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy is necessary. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Electric Literature of 34413-35-9

The Article related to review safety efficacy pyrazine derivative, chemical group 24, pyrazine derivatives, safety, sensory additives, Food and Feed Chemistry: Reviews and other aspects.Electric Literature of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On January 24, 2019, Tangherlini, Giovanni; Kalinin, Dmitrii V.; Schepmann, Dirk; Che, Tao; Mykicki, Nadine; Staender, Sonja; Loser, Karin; Wuensch, Bernhard published an article.COA of Formula: C8H10N2 The title of the article was Development of novel quinoxaline-based κ-opioid receptor agonists for the treatment of neuroinflammation. And the article contained the following:

Neuroinflammatory disorders, such as multiple sclerosis or exptl. autoimmune encephalomyelitis (EAE), an established mouse model mimicking part of the human pathol., are characterized by inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells, which cause demyelination and neurodegeneration. Disease onset and perpetuation are mediated by peripherally generated autoreactive T cells infiltrating into the central nervous system, where they are restimulated by antigen-presenting cells. Here, we show that newly designed peripherally active, potent, and selective κ-opioid receptor (KOR) agonists comprising the ethylenediamine KOR pharmacophore in a perhydroquinoxaline scaffold exhibit potent anti-inflammatory capacities in primary antigen presenting cells as well as T cells. In the EAE model, the secondary amine I and the triazole II were able to ameliorate disease severity and to delay disease onset by blocking effector T cell activation. Importantly, the beneficial effects were mediated via signaling through KOR because off-target effects were excluded by using KOR-deficient mouse mutants. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).COA of Formula: C8H10N2

The Article related to quinoxaline kappa opioid receptor agonist neuritis antiinflammatory multiple sclerosis, anti multiple sclerosis immunomodulator, Pharmacology: Structure-Activity and other aspects.COA of Formula: C8H10N2

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider