Day: November 10, 2022

Nakhi, Ali published the artcileAlCl3-mediated hydroarylation-heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest, HPLC of Formula: 39267-05-5, the main research area is diarylvinyl arylquinoxaline preparation aluminum chloride mediated hydroarylation heteroarylation; densely functionalized olefin arylquinoxaline mol docking sirtuin protein inhibitor.

An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, 2-(2,2-diarylvinyl)-3-arylquinoxalines, such as I, as potential inhibitors of sirtuins.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sahoo, Subas Chandra published the artcileDirect Aerobic Oxidative Reactions of 2-Hydroxyacetophenones, Quality Control of 40353-41-1, the main research area is phthalide preparation; isochromandione hydroxyacetophenone aerobic oxidation; quinoxaline preparation; diamine aryl hydroxyacetophenone aerobic oxidation; amide keto preparation; pyrrolidine hydroxyacetophenone aerobic oxidation.

Valuable and direct aerobic oxidation reactions of 2-hydroxyacetophenones R1C(O)CH2OH (R1 = thien-2-yl, 2H-1,3-benzodioxol-5-yl, 2-O2NC6H4, etc.) were explored. The concept was based on the in situ treatment of small quantities of aerobically formed α-keto aldehydes that drove the reactions to the corresponding products. This new strategy was applied for a variety of oxidative reactions of 2-hydroxyacetophenones, and valuable products such as phthalides I (R2 = H, 7-CH3O), quinoxalines II (R3 = H, 6,7-Cl2, 6-NO2) and α-keto amides R1(C(O))2X (X = pyrrolidin-1-yl) were obtained in good to high yields.

European Journal of Organic Chemistry published new progress about Amides, oxo Role: SPN (Synthetic Preparation), PREP (Preparation). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Quality Control of 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Bunz, Uwe H. F. published the artcileThe Palladium Way to N-Heteroacenes, Application In Synthesis of 25983-14-6, the main research area is heteroacene preparation palladium catalyst; review heteroacene acene preparation; N-heterocycles; acenes; electron transport materials; homogeneous catalysis; palladium.

A review with new data. Novel synthetic methodologies allow increasingly efficient access to known organic materials, as well as the preparation of otherwise inaccessible species. Pd-catalyzed coupling of aromatic dihalides to ortho-diaminoarenes furnishes embedded stable N,N’-dihydropyrazines expediently and in often excellent yields. The embedded N,N’-dihydropyrazines can then be oxidized by MnO2 to give substituted azatetracenes, azapentacenes, azahexacenes, and azaheptacenes, which are soluble, processable, and stable. This powerful Pd-catalyzed methodol. allows the preparation of azaacenes, including diaza-, tetraaza- and hexaazaacenes. In combination with ahsuitable Pd precursor, Buchwald-type biarylphosphines have been shown to give excellent results. Activated dihalides such as 2,3-dihaloquinoxalines are coupled easily under simplified conditions, whereas 2,3-dibromoacenes require more stringent conditions and advanced catalyst precursors. Pd catalysts effect the assembly of azaacenes with otherwise difficult to obtain substitution patterns. High yields and flexibility make this method most attractive.

Chemistry – A European Journal published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl dihalides). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Application In Synthesis of 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Teng, Min published the artcileSmall molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor, Formula: C8H2Cl4N2, the main research area is dichloroquinoxaline derivative preparation structure glucagon peptide hGLP1 receptor modulator.

Following the previous publication describing the biol. profiles, the authors herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small mol. agonists for the hGLP-1 receptor.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Formula: C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Inoue, Mami published the artcileInherently Chiral Cavitand Curvature: Diastereoselective Oxidation of Tethered Allylsilanes, Formula: C9H6Cl2N2, the main research area is chiral cavitand tethered allylsilane preparation stereoselective oxidation; epoxide chiral cavitand tethered silane preparation.

Syntheses of inwardly and outwardly directed allylsilanes those are tethered to new inherently chiral cavitands are described. Oxidized with mCPBA, these allylsilanes result in diastereomeric mixtures of epoxide mols. Thus, it enables the authors to have comparative study of cavitand-structure diastereoselectivity relation, which revealed that an inward allylsilane group flanked by a dibenzo[f, h]quinoxaline and two bridged methylene groups have the best chem. yield and diastereoselection.

European Journal of Organic Chemistry published new progress about Epoxidation, stereoselective. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Formula: C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Liu, Yunkui published the artcileMultifold Bond Cleavage and Formation between MeOH and Quinoxalines (or Benzothiazoles): Synthesis of Carbaldehyde Dimethyl Acetals, Product Details of C12H8N2S, the main research area is quinoxaline methanol potassium persulfate cross coupling; quinoxalinyl carbaldehyde dimethyl acetal preparation green chem; benzothiazole methanol potassium persulfate cross coupling; benzothiazolyl carbaldehyde dimethyl acetal preparation green chem.

A K2S2O8-mediated direct cross-coupling of quinoxalines (or benzothiazoles) with methanol leading to 2-quinoxalinyl (or 2-benzothiazolyl) carbaldehyde di-Me acetals has been achieved. 2-Quinoxalinyl carbaldehyde di-Me acetals were readily converted into 2-quinoxalinyl carbaldehydes in good to excellent yields under acidic conditions. Preliminary mechanistic studies suggest that the reaction proceeds via multifold bond cleavage and formation between methanol and N-heterocycles involving a dioxygen-participated radical process. This method allows for the synthesis of a variety of 2-quinoxalinyl (or 2-benzothiazolyl) carbaldehyde di-Me acetals directly via cross-coupling of simple N-heterocyclic C-H bond and methanol under aldehyde-, acid-, and transition-metal-free conditions.

Journal of Organic Chemistry published new progress about Aryl aldehydes, heteroaryl Role: SPN (Synthetic Preparation), PREP (Preparation) (quinoxalinyl). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Product Details of C12H8N2S.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Isoda, Kyosuke published the artcileDipole-Driven Self-Organization of Liquid-Crystalline N-Heteroacene Derivatives Showing Redox-Properties, Product Details of C8H2Cl4N2, the main research area is dichloro trimethyldodecyloxytetraazanaphthacene preparation liquid crystal phase transition redox.

An introduction of halogen atoms to liquid-crystalline (LC) TANC derivatives to tune their electronic characters as well as the charge polarization on π-conjugated N-heteroacene framework was reported. The electroneg. Cl atoms can improve the electron-accepting property of LC TANC. Also, the induced charge polarization due to the substitution of Cl atoms generated an intrinsic dipole moment on π-conjugated N-heteroacene framework, which was able to serve as a driving force for stabilizing self-organization of N-heteroacene mols. in thin films.

ChemistrySelect published new progress about Dipole moment. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Product Details of C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lindner, Benjamin D. published the artcileSynthesis and Optical Properties of Diaza- and Tetraazatetracenes, Formula: C8H2Cl4N2, the main research area is diazatetracene tetraazatetracene preparation optical property.

A series of functionalized diaza- and tetraazatetracenes was synthesized, either by condensation of an aromatic diamine with an ortho-quinone/diethyloxalate followed by chlorination with POCl3 to give diazatetracenes or by palladium-catalyzed coupling of a phenylenediamine with various 2,3-dichloroquinoxalines to give tetraazatetracenes (after oxidation with MnO2). Representative examples included halogenated and nitrated derivatives The optical properties of these azatetracenes were discussed with respect to their mol. structures and substitution patterns. The diazatetracenes and tetraazatetracenes formed two different groups that had significantly different electronic structures and properties. Furthermore, 1,2,3,4-tetrafluoro-6,11-bis((triisopropylsilyl)ethynyl)benzo[b]phenazine was synthesized, which is the first reported fluorinated diazatetracene. Single-crystal X-ray anal. of this compound is reported.

Chemistry – A European Journal published new progress about Aryl fluorides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Formula: C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Thompson, Andrew J. published the artcileStructure-Activity Relationships of Quinoxaline-Based 5-HT3A and 5-HT3AB Receptor-Selective Ligands, Name: 2,3,6,7-Tetrachloroquinoxaline, the main research area is quinoxaline preparation serotonin 5HT3 subtype receptor selective ligand.

Until recently, discriminating between homomeric 5-HT3A and heteromeric 5-HT3AB receptors was only possible with ligands that bind in the receptor pore. This study describes the first series of ligands that can discriminate between these receptor types at the level of the orthosteric binding site. During a recent fragment screen, 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline (VUF10166) was identified as a ligand that displays an 83-fold difference in [3H]granisetron binding affinity between 5-HT3A and 5-HT3AB receptors. Fragment hit exploration, initiated from VUF10166 and 3-(4-methylpiperazin-1-yl)quinoxalin-2-ol, resulted in a series of compounds with higher affinity at either 5-HT3A or 5-HT3AB receptors. These ligands reveal that a single atom is sufficient to change the selectivity profile of a compound At the extremes of the new compounds were 2-amino-3-(4-methylpiperazin-1-yl)quinoxaline (I), which showed 11-fold selectivity for the 5-HT3A receptor, and 2-(4-methylpiperazin-1-yl)quinoxaline, which showed an 8.3-fold selectivity for the 5-HT3AB receptor. These compounds represent novel mol. tools for studying 5-HT3 receptor subtypes and could help elucidate their physiol. roles.

ChemMedChem published new progress about 5-HT3 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (5-HT3AB). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Name: 2,3,6,7-Tetrachloroquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Bouanane, Zohra published the artcileSynthesis, structural, catecholase, tyrosinase and DFT studies of pyrazoloquinoxaline derivatives, Safety of 2,3-Dichloro-6-methylquinoxaline, the main research area is pyrazolylquinoxaline derivative preparation copper ligand catecholase activity; mol structure pyrazolylquinoxaline copper complex DFT; electronic structure pyrazolylquinoxaline copper complex DFT.

Six functional multidentate ligands: 2,3-bis(3,5-dimethyl-1H-pyrazol-1-yl) quinoxaline L1, 2,3-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-nitroquinoxaline L2, 2,3-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylquinoxaline L3, 2-(3,5-dimethyl-1H-pyrazol-1-yl)-3-hydrazinyl-6-nitroquinoxaline L4, 2-chloro-3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylquinoxaline L5, 2-chloro-3-(3,5-dimethyl-1H-pyrazol-1-yl)quinoxaline L6, (I – VI) and a new copper (II) complex (VII) , were prepared and evaluated for their catecholase activities at aerobic conditions. We found that, the reaction rate depends on: the nature of the substituents in the quinoxaline ring, counter anion, metal, concentration of ligand and the used solvent. The complex obtained in-situ from reaction of one equivalent of ligand L1 and two equivalent of Cu(CH3COO)2 in methanol showed the highest oxidation rate activity (V = 33.48 μmol L-1. min-1). In addition, geometry optimizations of the complexes in order to get better insight into the geometry and the electronic structure and chem. reactivity were carried out by means of DFT calculations

Journal of Molecular Structure published new progress about Counterions (counterion effect on catecholase activity). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Safety of 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider