Teng, Min published the artcileSmall molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor, Formula: C8H2Cl4N2, the main research area is dichloroquinoxaline derivative preparation structure glucagon peptide hGLP1 receptor modulator.
Following the previous publication describing the biol. profiles, the authors herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small mol. agonists for the hGLP-1 receptor.
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Formula: C8H2Cl4N2.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider