Day: November 14, 2022

Guntreddi, Tirumaleswararao published the artcileElemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids, Quality Control of 40353-41-1, the main research area is aminophenol cinnamic acid decarboxylative coupling reaction; arylmethyl benzoxazole preparation; mercaptoaniline cinnamic acid decarboxylative coupling reaction; benzothiazole arylmethyl preparation; aminoaniline cinnamic acid decarboxylative coupling reaction; aryl quinoxaline preparation.

An easy and practical method was developed for the synthesis of 2-benzylbenzoxazoles and 2-benzylbenzothiazoles using sulfur mediated decarboxylative coupling of cinnamic acids with 2-hydroxyanilines and 2-mercaptoanilines resp. under metal- and solvent-free conditions. However, the reaction of 2-aminoanilines with cinnamic acids led to the formation of 2-arylquinoxalines under the same set of reaction conditions. The transformation was versatile and compatible with a number of functional groups.

RSC Advances published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Quality Control of 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Matsumura, Mio published the artcileSynthesis of 2-arylquinoxalines: triarylstibane-catalyzed oxidative cyclization of α-hydroxy ketones with 1,2-diamines under aerobic conditions, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline, the main research area is quinoxaline aryl preparation; diamine hydroxy ketone aerobic oxidative cyclization triarylstibane catalyst.

The reaction of α-hydroxy ketones ArC(O)CH2OH (Ar = Ph, 4-bromophenyl, 2-naphthyl, 2-thienyl, etc.) with 1,2-diamines such as benzene-1,2-diamine, 4,5-dibromobenzene-1,2-diamine, naphthalene-2,3-diamine, etc. in the presence of triphenylstibane (10 mol%) as catalyst led to the formation of 2-arylquinoxalines I (R1 = H, MeO, Me, Br, CN, CF3; R2 = H, MeO, Br, Me, CN; R1R2 = CH=CH-CH=CH) in moderate to good yield under aerobic conditions. This reaction is the first example of oxidative cyclization catalyzed by organoantimony compounds

Heterocycles published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Pei-Ming published the artcileA One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst, SDS of cas: 39267-05-5, the main research area is dichloroquinoxaline preparation green chem; aromatic diamine oxalic acid tandem heterocyclization silica gel catalyst.

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives I (R1 = H, H3CO, Cl, etc.; R2 = H, F, CH3, etc.; R3 = H, CH3; R1R2 = CH=CH-CH=CH). The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamines 2-H2N-3-R3-4-R1-5-R2C6HNH2 and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines I have been obtained in good to excellent overall yields.

Journal of Heterocyclic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, SDS of cas: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Pei-Ming published the artcileA One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst, Quality Control of 25983-14-6, the main research area is dichloroquinoxaline preparation green chem; aromatic diamine oxalic acid tandem heterocyclization silica gel catalyst.

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives I (R1 = H, H3CO, Cl, etc.; R2 = H, F, CH3, etc.; R3 = H, CH3; R1R2 = CH=CH-CH=CH). The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamines 2-H2N-3-R3-4-R1-5-R2C6HNH2 and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines I have been obtained in good to excellent overall yields.

Journal of Heterocyclic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Quality Control of 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Cho, Chan Sik published the artcileA recyclable copper catalysis in quinoxaline synthesis from α-hydroxyketones and o-phenylenediamines, Safety of 2-(Thiophen-2-yl)quinoxaline, the main research area is hydroxyketone phenylenediamine recyclable copper oxidative cyclization quinoxaline preparation; oxidative cyclization catalyst recyclable copper.

O-Phenylenediamines react with α-hydroxyketones in toluene at 100° in the presence of a catalytic amount of a copper catalyst along with MS 4 Å under O2 atmosphere to afford the corresponding quinoxalines in high yields. The catalytic system could be easily recovered and reused several times without any loss of catalytic activity.

Journal of Organometallic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Safety of 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lassagne, Frederic published the artcileA Combined Experimental and Theoretical Study of the Ammonium Bifluoride Catalyzed Regioselective Synthesis of Quinoxalines and Pyrido[2,3-b]pyrazines, Computed Properties of 40353-41-1, the main research area is arylenediamine dicarbonyl ammonium bifluoride regioselective cyclocondensation catalyst; quinoxaline preparation crystal mol structure; pyridopyrazine preparation crystal mol structure.

Ammonium bifluoride was efficiently used at a 0.5 mol% loading to catalyze the cyclocondensation of 1,2-arylenediamines with 1,2-dicarbonyl compounds at room temperature in methanol-water to give quinoxalines or pyrido[2,3-b]pyrazines in excellent yields. Importantly, 2,8-disubstituted quinoxalines and 3-substituted pyrido[2,3-b]pyrazines were regioselectively formed by the reaction of arylglyoxals with 3-methylbenzene-1,2-diamine or pyridine-2,3-diamine, resp. An anal. of the d. functional theory reactivity indexes explained the catalytic role of ammonium bifluoride.

Synthesis published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Computed Properties of 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Wang, Xiao-Tong published the artcileIridium-Catalyzed [4+2] Annulations of β-Keto Sulfoxonium Ylides and o-Phenylenediamines: Mild and Facile Synthesis of Quinoxaline Derivatives, Application of 2-(Thiophen-2-yl)quinoxaline, the main research area is quinoxaline synthesis iridium catalyzed cycloaddition keto sulfoxonium ylide phenylenediamine.

A synthetic method for quinoxaline derivatives from the [4+2] annulation of β-keto sulfoxonium ylides and o-phenylenediamine by using (Cp*IrCl2)2 catalyst is described [e.g., ylide I + 1,2-benzenediamine → quinoxaline II (98%) in presence of (Cp*IrCl2)2, AgSbF6 and NaHCO3 in dichloromethane]. This novel protocol features mild reaction conditions, moderate to excellent yields, wide substrate scope, and high functional-group compatibility. Moreover, this cyclization strategy was successfully applied in late-stage modification for structurally complex bioactive compounds

European Journal of Organic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Application of 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lassagne, Frederic published the artcileSaccharin as an organocatalyst for quinoxalines and pyrido[2,3-b]pyrazines syntheses, COA of Formula: C12H8N2S, the main research area is arylenediamine dicarbonyl cyclocondensation saccharin organocatalyst; quinoxaline preparation catalyst solvent effect green chem; pyridopyrazine regioselective preparation regioisomer catalyst solvent effect green chem.

A room-temperature procedure using saccharin as catalyst was described for the cyclocondensation of different 1,2-arylenediamines with various 1,2-dicarbonyl compounds, yielding either quinoxalines or pyrido[2,3-b]pyrazines. The reactions proceed in very short reaction times in MeOH, and the target heterocycles were isolated in quant. yields after addition of water, filtration, and drying. Substituted pyrido[2,3-b]pyrazines can also be reached regioselectively by reacting α-keto aldehydes with 2,3-diaminopyridine.

Synthetic Communications published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, COA of Formula: C12H8N2S.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zeng, Jiajun published the artcileA practical access to 1,2-dicarbonyls via oxidation of alkynes catalyzed by gold(I) immobilized on MCM-41, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline, the main research area is dicarbonyl preparation; alkyne oxidation MCM41 anchored diphenylphosphine gold complex; MCM41 anchored diphenylphosphine gold complex catalyst preparation.

The heterogeneous gold(I)-catalyzed oxidation of alkynes was achieved by using 2,3-dichloropyridine N-oxide as oxidant and MCM-41-anchored diphenylphosphine-gold(I) complex [MCM-41-Ph2P-AuNTf2] as the catalyst under mild and acid-free conditions, yielding diverse 1,2-dicarbonyls in good to excellent yields with easy recycling of the gold catalyst. The developed method is applicable to a wide variety of alkynes including internal or terminal alkynes, alkynyl ethers or thioethers and ynamides, and can tolerate a wide range of functional groups.

Journal of Organometallic Chemistry published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Zhang, Wei published the artcilePalladium-Catalyzed Chelation-Assisted Aromatic C-H Nitration: Regiospecific Synthesis of Nitroarenes Free from the Effect of the Orientation Rules, Related Products of quinoxaline, the main research area is arene palladium chelation assisted regiospecific ortho nitration catalyst; nitroarene preparation; aryl oxime palladium chelation assisted regiospecific ortho nitration catalyst; nitro aryl ketone preparation.

A palladium-catalyzed chelation-assisted ortho-nitration of aryl C-H bond is described. A range of azaarenes such as 2-arylquinoxalines, pyridines, quinoline, and pyrazoles were nitrated with excellent chemo- and regioselectivity. Using the O-Me oximyl group as a removable directing group, the regiospecific synthesis of a variety of o-nitro aryl ketones was achieved starting from aryl ketones via a three-step process involving the Pd-catalyzed ipso-nitration of C-H bond as a key step. Mechanistic investigations support a silver-mediated radical mechanism involving Pd(II/III) and/or Pd(II/IV) catalytic cycles under oxidizing conditions.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider