Ceccarelli, Stefano published the artcileImidazo[1,2-a]quinoxalin-4-amines: a novel class of nonxanthine A1-adenosine receptor antagonists, Synthetic Route of 25983-14-6, the main research area is imidazoquinoxalinamine preparation A1 adenosine receptor binding.
The syntheses and A1 adenosine receptor affinities of a number of imidazo[1,2-a]quinoxalin-4-amines, e.g., I, are reported. Structure-activity relationships within the series and in comparison with other similar tricyclic nonxanthine adenosine antagonists are discussed, leading to a putative common binding mode of these nitrogen-containing heterocycles to A1 adenosine receptors. Secondary amino compounds displayed the best affinities toward A1 receptors, while the tertiary amines were almost devoid of activity, thus suggesting a crucial role for the hydrogen bond-forming 4-NH group. Remarkably higher potencies for 1-Me and N-cyclopentyl derivatives were also found. I (IRFI 165) is the most potent compound in this series, having Ki(A1) = 7.9 nM. It is also provided with a good A1 selectivity both vs. A2a and A3 subtypes and was selected for further pharmacol. studies.
European Journal of Medicinal Chemistry published new progress about Adenosine A1 receptor antagonists. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Synthetic Route of 25983-14-6.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider