Ghosh, Subhendu published the artcileAccess to Multifunctional AEEgens via Ru(II)-Catalyzed Quinoxaline-Directed Oxidative Annulation, Safety of 2-(Thiophen-2-yl)quinoxaline, the main research area is ruthenium catalyzed quinoxaline oxidative annulation aggregation induced emission.
Multifaceted application potential of AEEgens in bio-imaging, theranostic, chemo/bio sensors, mechanochromic, solar cells and organic photoelectronic opens up a new research paradigm to develop and design more such compounds Herein, quinoxaline N-directed Ru(II)-catalyzed oxidative annulation of 2-arylquinoxalines with internal alkynes leads to the formation of highly luminescent annulated quaternary ammonium salts in the presence of Cu(OAc)2.H2O oxidant. While the synthesized compounds exhibit emissions in green to yellow region with large Stoke shifts and reasonable quantum yields, their DFT calculation display 3D twisted conformation bearing donor-π-acceptor (D-π-A) configuration, where the two Ph moieties could serve as the donors and the extended quinoxaline core as the acceptor. Single crystal anal. of quaternary salt 3aa, depicts the presence of multiple intermol. non-covalent and weak π-π interactions that are possibly responsible for the luminescent behavior in crystalline as well as solid state. Advent of AEE in quinoxalinium salt 3aa in DMF/water is due to the restriction of intramol. motion (RIM) and suppression of intermol. charge transfer in aggregated state. AEEgen 3aa unveils reversible mechanochromism on changing from crystalline to amorphous state upon grinding and returned back to the crystalline state upon DCM fuming, where a few of such compounds are utilized for development of latent fingerprints on an adhesive tape. Furthermore, a representative group of synthesized luminescent quinoxalinium salts portray dose dependent cell growth inhibition of HeLa cells with concomitant cell arrest in G1 phases. Hence, these AEE luminogens are not only attractive as luminescent “”light-up”” probes for cell imaging, but also important as anticancer agents.
ACS Omega published new progress about Aggregation-induced emission enhancement. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Safety of 2-(Thiophen-2-yl)quinoxaline.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider