Nakhi, Ali published the artcilePyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: Their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay, Name: 2,3-Dichloro-6-methylquinoxaline, the main research area is luciferase reporter gene assay false pos result; pyrroloquinoxaline preparation inhibitor firefly luciferase.
2-Substituted pyrrolo[2,3-b]quinoxalines having free NH were prepared directly from 3-alkynyl-2-chloroquinoxalines in a single pot by using readily available and inexpensive methanesulfonamide (or p-toluenesulfonamide) as an ammonia surrogate. The reaction proceeded in the presence of Cu(OAc)2 affording the desired product in moderate yield. The crystal structure anal. of a representative compound and its supramol. interactions are presented. Some of the compounds synthesized exhibited inhibitory activities against luciferase that was supported by the predictive binding mode of these compounds with luciferase enzyme through mol. docking studies. The key observations disclosed here can alert users of luciferase reporter gene assays for possible false pos. results due to the direct inhibition of luciferase.
Bioorganic & Medicinal Chemistry Letters published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Name: 2,3-Dichloro-6-methylquinoxaline.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider