Day: November 15, 2022

Mohan Saini, Kapil published the artcileTrifluoroacetic Acid Mediated One-Pot Synthesis of Furo-Fused Quinoxalines/Pyrazines, Synthetic Route of 25983-14-6, the main research area is furoquinoxaline preparation; dichloroquinoxaline alkyne cyclization copper palladium catalyst; furopyrazine preparation; pyrazine alkyne cyclization copper palladium catalyst.

A trifluoroacetic acid promoted step-economical one-pot approach to the synthesis of furo-fused quinoxalines/ I (R = C6H5, 4-CF3C6H4, thiophen-3-yl, etc.; R1, R2 = H, Me, Cl)/pyrazines II (R3 = 2-Me, 4-Et, 4-nBu, etc.) by the reaction of 2,3-dichloroquinoxalines such as 2,3-dichloroquinoxaline, 2,3-dichloro-6-methylquinoxaline, 2,3-dichloro-6,7-dimethylquinoxaline, 2,3,6,7-tetrachloroquinoxaline /2,3-dichloropyrazine with alkynes RCCH is described. The reaction involves a selective in-situ Sonogashira coupling step and a hydroxylation followed by a metal-free 5-endo-dig cyclization. Preliminary experiments show that trifluoroacetic acid acts as a source of oxygen for the oxyarylation step, and isotopic labeling studies support the proposal that the mechanistic pathway involves activation of the alkyne by the acidic medium. Various kinds of substituents are tolerated, which should prove valuable for structural and biol. investigations.

European Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Synthetic Route of 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Nguyen, Le Anh published the artcileSulfur-Catalyzed Oxidative Condensation of Aryl Alkyl Ketones with o-Phenylenediamines: Access to Quinoxalines, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline, the main research area is quinoxaline preparation; aryl alkyl ketone phenylenediamine oxidative condensation sulfur catalyst; naphthoquinoxaline preparation; alpha tetralone phenylenediamine oxidative condensation sulfur catalyst.

Here catalytic activity of elemental sulfur in the oxidative condensation of o-phenylenediamines with acetophenones in DMSO to provide quinoxalines I [R = H; R1 = Ph, 4-MeC6H4, 2-FMeC6H4, etc.] was reported. The method was also extended to α-tetralones, propiophenones (R=Me) as well as higher homologs (R=Et, n-Pr) in place of acetophenones, leading to a wide range of naphthoquinoxalines II [R2 = H, 3-OMe, 2-F, etc.]and 3-substituted 2-arylquinoxalines I [R = Me, Et, 2-FMeC6H4, etc.].

Advanced Synthesis & Catalysis published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Fuerstner, Alois published the artcileIron-Catalyzed Cross-Coupling Reactions, Related Products of quinoxaline, the main research area is iron complex cross coupling catalyst organometallic compound; aryl chloride triflate tosylate coupling iron catalyst; heteroaryl chloride triflate tosylate coupling iron catalyst; green chem iron complex cross coupling catalyst.

Simple iron salts such as FeCln, Fe(acac)n (n = 2,3) or the salen complex I turned out to be highly efficient, cheap, toxicol. benign, and environmentally friendly precatalysts for a host of cross-coupling reactions of alkyl or aryl Grignard reagents, zincates, or organomanganese species with aryl and heteroaryl chlorides, triflates, and even tosylates. An “”inorganic Grignard reagent”” of the formal composition [Fe(MgX)2], prepared in situ, likely constitutes the propagating species responsible for the catalytic turnover, which occurs in many cases at an unprecedented rate even at or below room temperature Because of the exceptionally mild reaction conditions, a series of functional groups such as esters, ethers, nitriles, sulfonates, sulfonamides, thioethers, acetals, alkynes, and -CF3 groups are compatible. The method also allows for consecutive cross-coupling processes in one pot, as exemplified by the efficient preparation of compound II, and has been applied to the first synthesis of the cytotoxic marine natural product montipyridine (III). In contrast to the clean reaction of (hetero)aryl chlorides, the corresponding bromides and iodides are prone to a reduction of their C-X bonds in the presence of the iron catalyst.

Journal of the American Chemical Society published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Knapp, David M. published the artcileA General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates, Category: quinoxaline, the main research area is boronate methyliminodiacetic air stable preparation slow release cross coupling.

Many boronic acids, including 2-heterocyclic, vinyl, and cyclopropyl derivatives, are inherently unstable, which can limit their bench-top storage and/or efficient cross-coupling. The authors herein report the 1st general solution to this problem: in situ slow release of unstable boronic acids from the corresponding air-stable N-methyliminodiacetic acid (MIDA) boronates. This remarkably general approach has transformed all three classes of these unstable boronic acids into shelf-stable and highly effective building blocks for cross-coupling with a wide range of aryl and heteroaryl chlorides.

Journal of the American Chemical Society published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Category: quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gopalaiah, Kovuru published the artcileCopper-catalyzed aerobic oxidative coupling of o-phenylenediamines with 2-aryl/heteroarylethylamines: direct access to construct quinoxalines, Synthetic Route of 40353-41-1, the main research area is phenylenediamine arylethylamine copper catalyst aerobic oxidative coupling; aryl quinoxaline preparation green chem.

A copper-catalyzed oxidative coupling reaction of o-phenylenediamines with 2-aryl/heteroarylethylamines using mol. oxygen as an oxidant was developed. This approach provided a practical and direct access to construct quinoxalines in excellent yields at room temperature The reaction has a broad substrate scope and exhibited excellent functional-group tolerance. This method could be easily scaled up and applied to the synthesis of biol. active mols. bearing a quinoxaline structural scaffold.

Organic & Biomolecular Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Synthetic Route of 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider