Satish, Gandhesiri published the artcileI2Cu-mediated self-sorting domino reaction of aryl β-ketoesters into symmetrical 2-carboalkoxy-1,4-enediones: application to synthesis of pyrazine, β-carboline and quinoxalines, Category: quinoxaline, the main research area is enedione preparation stereoselective; ketoester domino reaction iodine copper acetate catalyst; quinoxaline carboline pyrazine preparation; diamine aryl enedione preparation nucleophilic addition iodine catalyst.
A self-sorting domino reaction of aryl β-ketoesters RC6H4C(O)CH2C(O)OCH2CH3 into sym. E:Z mixture of 1,4-enediones RC(O)C(CO2CH2CH3):CHC(O)R was reported by an I2/Cu system. The reaction proceeds through tandem iodination, self-dimerization and Krapcho dealkoxycarbonylation in one pot under open air condition. Further, E:Z mixture of 1,4-enediones RC(O)C(CO2CH2CH3):CHC(O)R were successfully employed for the synthesis of bioactive pyrazine, β-carboline and quinoxalines I via aza-Michael addition, intramol. cyclization and C-C bond cleavage of 1,3-dicarbonyl unit under mild reaction condition.
RSC Advances published new progress about Diastereoselective synthesis. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Category: quinoxaline.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider