Kumar, K. Shiva published the artcileAlCl3-mediated heteroarylation-cyclization strategy: one-pot synthesis of fused quinoxalines containing the central core of Lamellarin D, Application of 2,3-Dichloro-6-methylquinoxaline, the main research area is pyranoindole quinoxaline preparation enzyme antitumor; indole acid quinoxaline heteroarylation cyclization.
An inexpensive, practical and one-pot method has been developed for the synthesis of quinoxalines fused with pyrano[3,4-b]indole, I (R = H, CH3; R1 = H, CH3; R2 = H, CH3; R3 = H, F, CH3; R4 = H, CH3, CH2CH3, CH2=CHCH2) the central core of Lamellarin D. The methodol. involved construction of the central pyranone ring via an AlCl3-mediated heteroarylation-cyclization method. A number of compounds I are prepared by using this methodol., some of which were converted to the corresponding indol-3-ylquinoxaline derivatives II (R = H, CH3; R1 = H; R2 = H, CH3; R3 = H, CH3; R4 = H, CH2CH3). Several of the pyrano[3,4-b]indole fused quinoxalines I showed promising growth inhibition of cervical and lung cancer cells and good interactions with topoisomerase I in silico.
RSC Advances published new progress about Antitumor agents. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Application of 2,3-Dichloro-6-methylquinoxaline.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider