McKinney, Andrew M. published the artcileA rapid and efficient method for the reduction of quinoxalines, Application In Synthesis of 40353-41-1, the main research area is quinoxaline borane stereoselective reduction; hydroquinoxaline preparation.
Mono- and di-substituted alkyl- and arylquinoxalines are rapidly reduced in high yield to their resp. 1,2,3,4-tetrahydro derivatives by BH3 in THF solution In the case of the 2,3-di-substituted compounds, reduction is stereoselective yielding exclusively the cis-isomers. NaBH4 in AcOH also reduces alkyl- and arylquinoxalines, but proceeds with lower yields and often produces side products. NaBH4 in EtOH reduces quinoxaline and 2-methylquinoxaline in high yield. However, the reaction is very slow, whereas 2,3-dialkyl- and 2-arylquinoxalines are not efficiently reduced by NaBH4 in EtOH.
Journal of Heterocyclic Chemistry published new progress about Reduction, stereoselective. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Application In Synthesis of 40353-41-1.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider