Day: November 16, 2022

Yang, Yanchun published the artcileAn Efficient Synthesis of Quinoxalinone Derivatives as Potent Inhibitors of Aldose Reductase, SDS of cas: 39267-05-5, the main research area is oxoquinoxalinylacetic acid phenoxy anilino preparation aldose reductase inhibitor; quinoxalinone phenoxy anilino preparation aldose reductase inhibitor.

A novel and facile synthesis of quinoxalinone derivatives was developed in which a wide range of 3-chloroquinoxalin-2(1H)-ones as key intermediates can be generated chemo- and regioselectively in good yields from corresponding quinoxaline-2,3(1H,4H)-diones. This new protocol is arguably superior, as it allows the design and preparation of a variety of bioactive quinoxaline-based compounds, which are particularly effective in the treatment of diabetes and its complications. Through this procedure, a new class of quinoxalinone-based aldose reductase inhibitors were synthesized successfully. Most of the inhibitors, with an N1-acetic acid head group and a substituted C3-phenoxy side chain, proved to be potent and selective. Their IC50 values ranged from 11.4 to 74.8 nM. Among them, 2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid and 2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid were the most active. Structure-activity relationship and mol. docking studies highlighted the importance of the ether spacer in the C3-phenoxy side chains, and provided clear guidance on the contribution of substitutions both at the core structure and the side chain to activity.

ChemMedChem published new progress about Molecular docking. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, SDS of cas: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Yang, Yanchun published the artcileAn Efficient Synthesis of Quinoxalinone Derivatives as Potent Inhibitors of Aldose Reductase, Recommanded Product: 2,3,6,7-Tetrachloroquinoxaline, the main research area is oxoquinoxalinylacetic acid phenoxy anilino preparation aldose reductase inhibitor; quinoxalinone phenoxy anilino preparation aldose reductase inhibitor.

A novel and facile synthesis of quinoxalinone derivatives was developed in which a wide range of 3-chloroquinoxalin-2(1H)-ones as key intermediates can be generated chemo- and regioselectively in good yields from corresponding quinoxaline-2,3(1H,4H)-diones. This new protocol is arguably superior, as it allows the design and preparation of a variety of bioactive quinoxaline-based compounds, which are particularly effective in the treatment of diabetes and its complications. Through this procedure, a new class of quinoxalinone-based aldose reductase inhibitors were synthesized successfully. Most of the inhibitors, with an N1-acetic acid head group and a substituted C3-phenoxy side chain, proved to be potent and selective. Their IC50 values ranged from 11.4 to 74.8 nM. Among them, 2-(3-(4-bromophenoxy)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid and 2-(6-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid were the most active. Structure-activity relationship and mol. docking studies highlighted the importance of the ether spacer in the C3-phenoxy side chains, and provided clear guidance on the contribution of substitutions both at the core structure and the side chain to activity.

ChemMedChem published new progress about Molecular docking. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Recommanded Product: 2,3,6,7-Tetrachloroquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Paulus, Fabian published the artcileN,N’-Dihydrotetraazapentacenes (DHTA) in thin film transistors, HPLC of Formula: 25983-14-6, the main research area is dihydrotetraazapentacene thin film transistor hole mobility field effect.

The synthesis and structural properties of three N,N’-dihydrotetraazapentacenes (DHTA) are described. The different substitution pattern (H, F, Cl) of the dihydrotetraazapentacene body exhibited a significant effect on the optical, electronic and morphol. properties of the derivatives in thin films. The synthesized materials were investigated as active layers in top gate/bottom contact (BC/TG) transistors. The transistor performance of the dichlorinated derivative was almost independent on the processing conditions with an average hole mobility of ∼0.04 cm2 V-1 s-1 and best mobility values ranging from 0.07 to 0.11 cm2 V-1 s-1. Each of the three derivatives was found to exhibit an individual packing motif in solution grown crystals, determined by single crystal x-ray anal. Surprisingly, for all three materials a different polymorph formed in spin cast films explaining the observed morphol. and FET performance.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Crystal structure. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, HPLC of Formula: 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Gryko, Daniel T. published the artcileFluorescent dyes with 2-amino-4,7-diazaindole skeleton: synthesis and spectroscopy, Computed Properties of 25983-14-6, the main research area is fluorescence dye amino diazaindole skeleton synthesis spectroscopy nucleophilic substitution; Stokes shift quantum yield.

The reaction of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) with compounds possessing two vicinal chlorine atoms activated toward nucleophilic substitution has been studied. All derivatives bearing a 2,3-dichloropyrazine moiety react with DBU leading to fluorescent dyes. Among others, only 2,3-dichloro-1,4-naphthoquinone reacts giving the expected pentacyclic product albeit in a very low yield and accompanied by the product of hydrolysis. Spectroscopic properties of the synthesized compounds were studied. The dye formed from 5,6-dichloro-2,3-dicyanopyrazine exhibits a very high Stokes shift and strong dependence of the fluorescence quantum yield on solvent polarity.

Bulletin of the Chemical Society of Japan published new progress about Crystal structure. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Computed Properties of 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Engelhart, Jens U. published the artcileSubstituted Tetraaza- and Hexaazahexacenes and their N,N’-Dihydro Derivatives: Synthesis, Properties, and Structures, Related Products of quinoxaline, the main research area is hexaazahexacene preparation optical electronic property; dichloroquinoxaline diaminophenazine coupling palladium catalyst; tetraazahexacene preparation optical electronic property; diaminoanthracene dichloroquinoxaline coupling palladium catalyst; amination; cross-coupling; heteroacenes; oxidation; palladium.

The palladium-catalyzed coupling of a substituted o-diaminoanthracene and a substituted o-diaminophenazine to substituted 2,3-dichloroquinoxalines furnishes 10 differently substituted N,N’-dihydrotetraaza- or -hexaazahexacenes I (X = CH, N; R1 = H, Cl; R2 = H, F, Cl; R3 = H, F, Cl, NO2) with the quinoxaline group of the azaacenes carrying fluorine, chlorine, or nitro groups. The N,N’-dihydrotetraazahexacenes with hydrogen, chlorine, and fluorine substituents were oxidized to azaacenes, whereas only the parent N,N’-dihydrohexaazahexacenes, with hydrogen substituents, were oxidized by MnO2. The resultant azaacenes were characterized by their optical and spectroscopic data. In addition, single-crystal X-ray structures have been obtained for the parent tetraazahexacenes and their difluoro and chloro-substituted derivatives I (X = CH; R1 = H, Cl; R2 = H, F, Cl; R3 = H, F, Cl).

Chemistry – A European Journal published new progress about Coupling reaction. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sonawane, Yogesh A. published the artcileSynthesis of novel diphenylamine-based fluorescent styryl colorants and study of their thermal, photophysical, and electrochemical properties, Synthetic Route of 39267-05-5, the main research area is diphenylamine styryl fluorescent probe thermal stability Knoevenagel condensation.

Three novel “”Y””-shaped acceptor-π-donor-π-acceptor-type compounds were synthesized from 4,4′-(hexylimino)bis(benzaldehyde) as a donor and 2-methylthiazolo[4,5-b]quinoxaline derivatives as strong electron acceptors condensed by classical Knoevenagel condensation. Their absorption, emission, and thermal properties and electrochem. stability were investigated. It was found that the strong electron acceptor-donor chromophoric system of these compounds showed high Stokes shift, excellent thermal stability, and electrochem. reversibility. The solvatochromic behavior of these colorants was studied by using various solvents such as toluene, chloroform, Et acetate, THF, methanol, and N,N-dimethylformamide in increasing order of polarity. The dyes were characterized by means of elemental anal., 1H NMR, and mass spectrometry. Graphical abstract

Monatshefte fuer Chemie published new progress about Cyclic voltammetry. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Synthetic Route of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Wang, Zhaolin published the artcileDiscovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction, HPLC of Formula: 25983-14-6, the main research area is quinoxaline preparation hIgG hFcRn protein interaction antagonist autoimmune disease.

The neonatal Fc receptor, FcRn, prolongs the half-life of IgG in the serum and represents a potential therapeutic target for the treatment of autoimmune disease. Small mols. that block the protein-protein interactions of human IgG-human FcRn may lower pathogenic autoantibodies and provide effective treatment. A novel class of quinoxalines has been discovered as antagonists of the IgG:FcRn protein-protein interaction through optimization of a hit derived from a virtual ligand-based screen. Compound I was found to be the most potent with IC50 = 2 μM.

Bioorganic & Medicinal Chemistry Letters published new progress about Autoimmune disease. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, HPLC of Formula: 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Sastry, C. V. Reddy published the artcileSynthesis and biological activities of some 1,5-dihydro[1,2,4]ditriazolo[4,3-a:3′,4′-c]quinoxaline-1,6-diones, HPLC of Formula: 39267-05-5, the main research area is ditriazoloquinoxalinedione preparation pharmacol; antiallergic ditriazoloquinoxalinedione preparation; antimicrobial ditriazoloquinoxalinedione preparation; antiprotozoal ditriazoloquinoxalinedione preparation; anthelmintic ditriazoloquinoxalinedione preparation; nitrodihydroditriazoloquinoxalinedione preparation antiallergic.

Title compounds I (R = H, R1 = H, Cl, Me, NO2; R = NO2, Cl, Me, OMe, R1 = NO2) were prepared and tested for their antiallergic, antimicrobial, antiprotozoal and anthelmintic activities. I (R = H, NO2, Cl, R1 = NO2) had egg albumin-induced rat passive cutaneous anaphylaxis (PCA) activity >90% at 50 mg/kg.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Allergy inhibitors. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Morais, Victor M. F. published the artcileThermochemical study of chloropyrazines and chloroquinoxalines, Formula: C8H2Cl4N2, the main research area is enthalpy formation combustion vaporization sublimation chloropyrazine chloroquinoxaline; mol structure chloropyrazine chloroquinoxaline DFT.

The standard (p° = 0.1 MPa) molar enthalpies of formation for liquid 2-chloropyrazine and crystalline 2,6-dichloropyrazine, 2,3-dichloroquinoxaline and 2,3,6,7-tetrachloroquinoxaline were derived from the standard molar enthalpies of combustion, in oxygen, to yield CO2(g), N2(g), and HCl·600H2O(l), at the temperature T = 298.15 K, measured by rotating-bomb combustion calorimetry. The standard molar enthalpies of vaporization or of sublimation, at T = 298.15 K, were measured by Calvet microcalorimetry. D. functional theory with the B3LYP functional and two different basis sets, 6-31G* and 6-311G*, was used to optimize the geometries of all chloro-substituted pyrazines and some chloro-substituted quinoxalines. The calculation of the energy of isodesmic reactions allowed the estimation of the standard molar enthalpies of formation in the gas phase for all compounds, including some not studied exptl.

Journal of Chemical Thermodynamics published new progress about Combustion enthalpy. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Formula: C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Li, Xiaoqing published the artcileAn iodobenzene-catalysed domino route toward quinoxaline derivatives from simple ketones and o-phenylenediamines in one pot, SDS of cas: 40353-41-1, the main research area is quinoxaline derivative preparation iodobenzene catalyst.

An iodobenzene-catalyzed domino route to quinoxalines from ketones and o-phenylenediamines in one pot was developed. This transformation consisted of the generation of Koser’s generation, α-tosyloxylation of ketones, nucleophilic substitution and intramol. dehydration with o-phenylenediamines, and dehydrogenation.

Journal of Chemical Research published new progress about Dehydration reaction. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, SDS of cas: 40353-41-1.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider