Peng, Yun published the artcileReactivity Umpolung of the C=N Bond in Quinoxaline Scaffold Enabling Direct Nucleophilic Attack of Alkyl Grignard Reagents at the N-Terminus, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline, the main research area is quinoxaline Grignard reagent tandem regioselective alkylation carbon bond cleavage; quinoxalinone preparation.
The reactivity umpolung of the C=N bond in the quinoxaline scaffold was successfully realized for the first time by introduction of a formyl or an acyl group adjacent to the C-position of the C=N moiety. The reversed reactivity of the C=N bond thus enabled direct nucleophilic attack of alkyl Grignard reagents at the N-terminus rather than the C-terminus, thereby providing an unprecedented and efficient method for the synthesis of quinoxalin-2(1H)-one derivatives involving a tandem N-alkylation/C-C bond cleavage process.
Organic Letters published new progress about Alkylation, regioselective. 40353-41-1 belongs to class quinoxaline, name is 2-(Thiophen-2-yl)quinoxaline, and the molecular formula is C12H8N2S, Recommanded Product: 2-(Thiophen-2-yl)quinoxaline.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider