Smits, Rogier A. published the artcileFragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo, COA of Formula: C8H2Cl4N2, the main research area is methylpiperazin quinoxaline derivative preparation structure H4 receptor ligand antiinflammatory.
Using a previously reported flexible alignment model the authors have designed, synthesized, and evaluated a series of compounds at the human histamine H4 receptor (H4R) from which 2-(4-methyl-piperazin-1-yl)-quinoxaline (I) was identified as a new lead structure for H4R ligands. Exploration of the structure-activity relationship (SAR) of this scaffold led to the identification of 6,7-dichloro 3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one (VUF 10214, II) and 2-benzyl-3-(4-methyl-piperazin-1-yl)quinoxaline (VUF 10148, III) as potent H4R ligands with nanomolar affinities. In vivo studies in the rat reveal that compound II has significant anti-inflammatory properties in the carrageenan-induced paw-edema model.
Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, COA of Formula: C8H2Cl4N2.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider