Day: November 17, 2022

Ammar, Y. A. published the artcileSynthesis of some newer thiazolo and thiadiazino derivatives from 6-methyl- or 6-nitro-2,3-dichloroquinoxalines, HPLC of Formula: 39267-05-5, the main research area is chloroquinoxaline cyclocondensation thiourea; quinoxaline dichloro cyclocondensation thiourea; diquinoxalinodithiin; aminoiminodihydrothiazoloquinoxaline preparation cyclization carbon disulfide; thiazoloquinoxaline preparation reaction.

Interaction of 6-methyl- or 6-nitro-2,3-dichloroquinoxaline with thiourea in EtOH led to the formation of diquinoxalinodithiin derivatives I (R = Me, NO2) together with 2-imino-2,3-dihdyrothiazolo[4,5-b]quinoxalines II (R1 = H). 7-Methyl- or 7-nitro-3-amino-2-imino-2,3-dihydrothiazolo[4,5-b]quinoxalines II (R1 = NH2) were also prepared Reaction of II (R1 = NH2) with CS2 gave the corresponding 2-mercaptothiadiazine[5,6-b]quinoxaline derivatives III. Other reactions are also described.

Journal of the Indian Chemical Society published new progress about chloroquinoxaline cyclocondensation thiourea; quinoxaline dichloro cyclocondensation thiourea; diquinoxalinodithiin; aminoiminodihydrothiazoloquinoxaline preparation cyclization carbon disulfide; thiazoloquinoxaline preparation reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, HPLC of Formula: 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Carmeli, Mira published the artcileA new efficient route for the formation of quinoxaline N-oxides and N,N’-dioxides using HOFCH3CN, COA of Formula: C8H2Cl4N2, the main research area is quinoxaline oxide dioxide preparation acetonitrile hydrofluoride oxygen transfer.

HOFCH3CN, a very efficient oxygen-transfer agent made readily from fluorine and aqueous acetonitrile, was reacted with various quinoxaline derivatives to give the corresponding mono N-oxides and especially the N,N’-dioxides in very good yields under mild conditions and short reaction times.

Journal of Organic Chemistry published new progress about Oxidation. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, COA of Formula: C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Obafemi, Craig A. published the artcilePermanganate oxidation of quinoxaline and its derivatives, Application In Synthesis of 39267-05-5, the main research area is permanganate oxidation quinoxaline; chloroquinoxaline permanganate oxidation; quinoxalinone permanganate oxidation; quinoxalinedione permanganate oxidation.

The oxidation reactions of a series of quinoxaline derivatives, using KMnO4 in the presence or absence of NaOH, are described. Neutral oxidation of 2-chloro- and 2,3-dichloroquinoxalines afforded the corresponding chloro- and dichloropyrazinedicarboxylic acids in good yield. On the other hand, oxidation of quinoxalin-2(1H)-one and 1,4-dihydroquinoxaline-2,3-dione derivatives in alk. medium gave different products, with the quinoxalin-2(1H)-one forming 1,4-dihydroquinoxaline-2,3-dione, while various substituted quinoxalin-2,3-dione derivatives gave dimeric products.

Helvetica Chimica Acta published new progress about Oxidation. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Application In Synthesis of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Lee, Sujin published the artcileNanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1, SDS of cas: 25983-14-6, the main research area is triazolo quinoxaline analog preparation renal urea transporter inhibitor diuretic.

Urea transporter A (UT-A) isoforms encoded by the Slc14a2 gene are expressed in kidney tubule epithelial cells, where they facilitate urinary concentration UT-A1 inhibition is predicted to produce a unique salt-sparing diuretic action in edema and hyponatremia. Here we report the discovery of 1,2,4-triazoloquinoxalines and the anal. of 37 synthesized analogs. The most potent compound, 8ay, containing 1,2,4-triazolo[4,3-a]quinoxaline-substituted benzenesulfonamide linked by an aryl ether, rapidly and reversibly inhibited UT-A1 urea transport by a noncompetitive mechanism with IC50 ≈ 150 nM; the IC50 was ∼2 μM for the related urea transporter UT-B encoded by the Slc14a1 gene. Mol. modeling suggested a putative binding site on the UT-A1 cytoplasmic domain. In vitro metabolism showing quinoxaline ring oxidation prompted the synthesis of metabolically stable 7,8-difluoroquinoxaline analog 8bl, which when administered to rats produced marked diuresis and reduced urinary osmolality. 8bl has substantially improved UT-A1 inhibition potency and metabolic stability compared with prior compounds

Journal of Medicinal Chemistry published new progress about Diuretics. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, SDS of cas: 25983-14-6.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Kolli, Sunder Kumar published the artcileLigand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: An unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis, Related Products of quinoxaline, the main research area is thienyl pyrroloquinoxaline preparation PDE4 inhibitor apoptosis hepatotoxicity; Apoptosis; PDE4; Palladium; Pyrroloquinoxaline; Zebrafish.

The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacol. properties when tested in vitro and in zebrafish embryos.

European Journal of Medicinal Chemistry published new progress about Apoptosis. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Related Products of quinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Romer, Duane R. published the artcileSynthesis and fungicidal activity of 1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline, the main research area is quinoxaline derivative fungicide structure activity.

A series of 11 1,4-dithiino[2,3-b]quinoxaline-2,3-dicarbonitriles (I, R1 = H, Cl, CF3, MeO, CN, Ac, NO2; R2 = H, Cl Me, NO2) was prepared by reaction of 2,3-dichloroquinoxalines with disodium (Z)-2,3-dimercapto-2-butenedinitrile in N,N-dimethylformamide. These products were tested for in-vitro fungicidal activity by a Min. Inhibitory Concentration method. Several of these compounds showed broad-spectrum fungicidal activity. The activity exhibited by these compounds was greatly dependent upon the substituents of the quinoxaline ring, with the nitro-substituted derivatives showing the highest levels of antifungal activity. None of the compounds prepared, however, showed fungicidal activity comparable to that of the com. fungicides screened.

Pesticide Science published new progress about Fungicides. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Recommanded Product: 2,3-Dichloro-6-methylquinoxaline.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Tomoda, Haruhiko published the artcileSynthesis and physical properties of pyrido[1′,2′:1,2]imidazo[4,5-b]quinoxalines, Product Details of C8H2Cl4N2, the main research area is pyridoimidazoquinoxaline preparation; fluorescence substituent effect pyridoimidazoquinoxaline preparation.

A series of 2-, 3-, or 4-substituted pyrido[1′,2′:1,2]imidazo[4,5-b]quinoxalines (PIQs) were synthesized in moderate-to-good yields by the reactions of 2-amino-3-chloroquinoxalines (ACQs) with substituted pyridines, and the structures were established. The reactions of ACQs with 3-phenoxycarbonyl and 3-benzoylpyridines gave the corresponding 2-substituted PIQs, while those with 3-Me, 3-Et, 3-benzyl, 3-Ph, 3-ethoxycarbonyl, and 3-acetylpyridines gave the corresponding 4-substituted PIQs. PIQ derivatives having substituents at the 2,4,8- and/or 9-positions were also studied. The spectroscopic and electrochem. properties of a series of PIQs derivatives were studied. PIQ showed a strong green fluorescence at 481.5 and 505 nm (F = 0.40) in ethanol. The introduction of substituents at the 3 position of PIQ altered the color of the fluorescence from blue to green without deteriorating the high quantum yield of PIQ. All of the derivatives showed strong (blue to orange) fluorescence in both solution and the solid state.

Bulletin of the Chemical Society of Japan published new progress about Fluorescence. 25983-14-6 belongs to class quinoxaline, name is 2,3,6,7-Tetrachloroquinoxaline, and the molecular formula is C8H2Cl4N2, Product Details of C8H2Cl4N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Romer, Duane R. published the artcileSynthesis of 2,3-dichloroquinoxalines via Vilsmeier reagent chlorination, Product Details of C9H6Cl2N2, the main research area is quinoxaline dichloro preparation Vilsmeier reagent chlorination dihydroxyquinoxaline.

A convenient and high-yielding synthesis of 2,3-dichloroquinoxalines from the corresponding 2,3-dihydroxyquinoxalines has been developed. Treatment of a slurry of the 2,3-dihydroxyquinoxaline with N,N-dimethylformamide in the presence of excess thionylchloride in 1,2-dichloroethane results in the rapid and high-yielding formation of the 2,3-dichloroquinoxaline derivatives Simplified workup and purification procedures for these compounds are also described.

Journal of Heterocyclic Chemistry published new progress about Chlorination. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Product Details of C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Ahmad, Yusuf published the artcileQuinoxaline derivatives. XI. Reaction of quinoxaline 1,4-dioxide and some of its derivatives with acetyl chloride, Formula: C9H6Cl2N2, the main research area is quinoxaline dioxide reaction; acetyl chloride reaction; chloroquinoxaline dioxide.

Quinoxaline 1,4-dioxide with AcCl gives 6-chloroquinoxaline 1-oxide (I). On heating, and progressively increasing the time of reaction, the yield of I increases, and 3-chloroquinoxaline 1-oxide, and 6.7-dichloroquinoxaline appear as addnl. products. 7-Ethoxy-, 7-methoxy-, 7-methylquinoxaline 1,4-dioxides show a similar behavior, giving corresponding 6-chloro, and 3-chloro derivatives as main products. Further increase in the reaction time results in the formation of 2,6-dichloro and 2,3-dichloro compounds as addnl. products. However, none of the 2-chloro 4-oxide derivatives were isolated. The mechanisms for these transformations were proposed and discussed.

Journal of Organic Chemistry published new progress about Chlorination. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Formula: C9H6Cl2N2.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Babu, P. Vijaya published the artcileLigand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo, Synthetic Route of 39267-05-5, the main research area is PDE4 luciferase mouth cancer cell proliferation zebrafish; pyrroloquinoxaline preparation PDE4 inhibitor; dichloroquinoxaline intramol Heck reaction.

A series of 1,3-disubstituted pyrrolo[2,3-b]quinoxalines was designed for the potential inhibition of PDE4 without inhibiting luciferase. A ligand/PTC (phase transfer catalyst) free intramol. Heck cyclization strategy was used to prepare these compounds, some of which showed significant inhibition of PDE4B (IC50 ≈ 5-14 μM) and growth inhibition of oral cancer cells (CAL 27) but not inhibition of luciferase in vitro. They also showed acceptable safety profiles but no apoptosis in zebrafish embryos.

Organic & Biomolecular Chemistry published new progress about Heck reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Synthetic Route of 39267-05-5.

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider