Babu, P. Vijaya published the artcileLigand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo, Synthetic Route of 39267-05-5, the main research area is PDE4 luciferase mouth cancer cell proliferation zebrafish; pyrroloquinoxaline preparation PDE4 inhibitor; dichloroquinoxaline intramol Heck reaction.
A series of 1,3-disubstituted pyrrolo[2,3-b]quinoxalines was designed for the potential inhibition of PDE4 without inhibiting luciferase. A ligand/PTC (phase transfer catalyst) free intramol. Heck cyclization strategy was used to prepare these compounds, some of which showed significant inhibition of PDE4B (IC50 ≈ 5-14 μM) and growth inhibition of oral cancer cells (CAL 27) but not inhibition of luciferase in vitro. They also showed acceptable safety profiles but no apoptosis in zebrafish embryos.
Organic & Biomolecular Chemistry published new progress about Heck reaction. 39267-05-5 belongs to class quinoxaline, name is 2,3-Dichloro-6-methylquinoxaline, and the molecular formula is C9H6Cl2N2, Synthetic Route of 39267-05-5.
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider