Colgan, Stephen T. published the artcileUse of Activated Carbon in Packaging to Attenuate Formaldehyde-Induced and Formic Acid-Induced Degradation and Reduce Gelatin Cross-Linking in Solid Dosage Forms, Category: quinoxaline, the publication is Journal of Pharmaceutical Sciences (2016), 105(7), 2027-2031, database is CAplus and MEDLINE.
Formaldehyde and formic acid are reactive impurities found in commonly used excipients and can be responsible for limiting drug product shelf-life. Described here is the use of activated carbon in drug product packaging to attenuate formaldehyde-induced and formic acid-induced drug degradation in tablets and crosslinking in hard gelatin capsules. Several pharmaceutical products with known or potential vulnerabilities to formaldehyde-induced or formic acid-induced degradation or gelatin crosslinking were subjected to accelerated stability challenges in the presence and absence of activated carbon. The effects of time and storage conditions were determined For all of the products studied, activated carbon attenuated drug degradation or gelatin crosslinking. This novel use of activated carbon in pharmaceutical packaging may be useful for enhancing the chem. stability of drug products or the dissolution stability of gelatin-containing dosage forms and may allow for the (1) extension of a drug product’s shelf-life when the limiting attribute is a degradation product induced by a reactive impurity, (2) marketing of a drug product in hotter and more humid climatic zones than currently supported without the use of activated carbon, and (3) enhanced dissolution stability of products that are vulnerable to gelatin crosslinking.
Journal of Pharmaceutical Sciences published new progress about 375815-87-5. 375815-87-5 belongs to quinoxaline, auxiliary class Neuronal Signaling,AChR,Natural product, name is 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-dihydroxysuccinate, and the molecular formula is C17H19N3O6, Category: quinoxaline.
Referemce:
https://en.wikipedia.org/wiki/Quinoxaline,
Quinoxaline | C8H6N2 | ChemSpider