Di Rocco, Daniel A. published the artcileLate-stage functionalization of biologically active heterocycles through photoredox catalysis, Quality Control of 375815-87-5, the publication is Angewandte Chemie, International Edition (2014), 53(19), 4802-4806, database is CAplus and MEDLINE.
The direct C-H functionalization of heterocycles has become an increasingly valuable tool in modern drug discovery. However, the introduction of small alkyl groups, such as Me, by this method has not been realized in the context of complex mol. synthesis since existing methods rely on the use of strong oxidants and elevated temperatures to generate the requisite radical species. Herein, the authors report the use of stable organic peroxides activated by visible-light photoredox catalysis to achieve the direct methyl-, ethyl-, and cyclopropylation of a variety of biol. active heterocycles. The simple protocol, mild reaction conditions, and unique tolerability of this method make it an important tool for drug discovery.
Angewandte Chemie, International Edition published new progress about 375815-87-5. 375815-87-5 belongs to quinoxaline, auxiliary class Neuronal Signaling,AChR,Natural product, name is 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-dihydroxysuccinate, and the molecular formula is C17H19N3O6, Quality Control of 375815-87-5.
Referemce:
https://en.wikipedia.org/wiki/Quinoxaline,
Quinoxaline | C8H6N2 | ChemSpider