Ji, Yining published the artcileInnate C-H trifluoromethylation of heterocycles, HPLC of Formula: 375815-87-5, the publication is Proceedings of the National Academy of Sciences of the United States of America (2011), 108(35), 14411-14415, S14411/1-S14411/166, database is CAplus and MEDLINE.
Direct methods for the trifluoromethylation of heteroaromatic systems are in extremely high demand in nearly every sector of chem. industry. Here the authors report the discovery of a general procedure using a bench-top stable trifluoromethyl radical source that functions broadly on a variety of electron deficient and rich heteroaromatic systems and demonstrates high functional group tolerance. This C-H trifluoromethylation protocol is operationally simple (avoids gaseous CF3I), scalable, proceeds at ambient temperature, can be used directly on unprotected mols., and is demonstrated to proceed at the innately reactive positions of the substrate. The unique and orthogonal reactivity of the trifluoromethyl radical relative to aryl radicals has also been investigated on both a complex natural product and a pharmaceutical agent. Finally, preliminary data suggest that the regioselectivity of C-H trifluoromethylation can be fine-tuned simply by judicious solvent choice. The target compounds thus formed included trifluoromethyl Chantix [varencline 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine].
Proceedings of the National Academy of Sciences of the United States of America published new progress about 375815-87-5. 375815-87-5 belongs to quinoxaline, auxiliary class Neuronal Signaling,AChR,Natural product, name is 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline (2R,3R)-2,3-dihydroxysuccinate, and the molecular formula is C17H19N3O6, HPLC of Formula: 375815-87-5.
Referemce:
https://en.wikipedia.org/wiki/Quinoxaline,
Quinoxaline | C8H6N2 | ChemSpider