Sun, Ji-Fu published the artcileCaSR and calpain contribute to the ischemia reperfusion injury of spinal cord, Recommanded Product: N-(Adamantan-1-yl)quinoxaline-2-carboxamide, the publication is Neuroscience Letters (2017), 49-55, database is CAplus and MEDLINE.
Spinal cord ischemia reperfusion injury (SCIRI) can cause spinal cord dysfunction and even devastating paraplegia. Calcium-sensing receptor (CaSR) and calpain are two calcium related mols. which have been reported to be involved in the ischemia reperfusion injury of cardiomyocytes and the subsequent apoptosis. Here, we studied the expression of CaSR and calpain in spinal cord neurons and tissues, followed by the further investigation of the role of CaSR/calpain axis in the cellular apoptosis process during SCIRI. The results of in vitro and in vivo studies showed that the expression of CaSR and calpain in spinal cord neurons increased during SCIRI. Moreover, the CaSR agonist GdCl3 and antagonist NPS-2390 enhanced or decreased the expression of CaSR and calpain resp. The expressions of CaSR and calpain were also consistent with the cellular apoptosis in spinal cord. Taken together, CaSR-calpain contributes to the SCIRI apoptosis, and CaSR antagonist might be a helpful drug for alleviating SCIRI.
Neuroscience Letters published new progress about 226878-01-9. 226878-01-9 belongs to quinoxaline, auxiliary class Neuronal Signaling,mGluR, name is N-(Adamantan-1-yl)quinoxaline-2-carboxamide, and the molecular formula is C6H5F4NO3S, Recommanded Product: N-(Adamantan-1-yl)quinoxaline-2-carboxamide.
Referemce:
https://en.wikipedia.org/wiki/Quinoxaline,
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