Vanejevs, Maksims published the artcilePositive and Negative Modulation of Group I Metabotropic Glutamate Receptors, Application In Synthesis of 226878-01-9, the publication is Journal of Medicinal Chemistry (2008), 51(3), 634-647, database is CAplus and MEDLINE.
A discriminating pharmacophore model for noncompetitive metabotropic glutamate receptor antagonists of subtype 1 (mGluR1) was developed that facilitated the discovery of moderately active mGluR1 antagonists. One scaffold was selected for the design of several focused libraries where different substitution patterns were introduced. This approach facilitated the discovery of potent mGluR1 antagonists, as well as pos. and neg. mGluR5 modulators, because both receptor subtypes share similar binding pockets. For mGluR1 antagonists, a homol. model of the mGlu1 receptor was established, and a putative binding mode within the receptor’s transmembrane domain was visualized.
Journal of Medicinal Chemistry published new progress about 226878-01-9. 226878-01-9 belongs to quinoxaline, auxiliary class Neuronal Signaling,mGluR, name is N-(Adamantan-1-yl)quinoxaline-2-carboxamide, and the molecular formula is C9H5ClO4S, Application In Synthesis of 226878-01-9.
Referemce:
https://en.wikipedia.org/wiki/Quinoxaline,
Quinoxaline | C8H6N2 | ChemSpider