Zhang, Wei-hua published the artcileCalcium sensing receptor is involved in neonate rat cardiomyocyte apoptosis induced by hypoxia/reoxygenation via regulating calcium concentration in mitochondria, Formula: C19H21N3O, the publication is Harbin Yike Daxue Xuebao (2012), 46(6), 534-538, database is CAplus.
Calcium sensing receptor (CaR) activation plays a role in the regulation of SR-mitochondrial inter-organelle Ca2+ signaling, causing apoptosis during ischemia/reperfusion (I/R). Neonatal rat cardiomyocytes were subjected to 3 h of hypoxia, followed by 6 h of reoxygenation. Ca2+ m were determined using x-rhod-1 and the mitochondrial membrane potential was detected with JC-1 during reoxygenation. The apoptotic rates detected by Hoechst33342 were lower in NPS-2390 + Ca + Ni + Cd + H-Re (±4)%, 2-APB + Ca + Ni + Cd + H-Re (18±4)% and Ru + Ca + Ni + Cd + H-Re (23±5)% groups than H-Re (33±6)%, Ca+Ni+Cd+H-Re (31±5)% and Gd+Ni+Cd+HRe (34±3)% groups. [Ca 2+] m was increased in the Ca + Ni + Cd + H-Re group. The mitochondria transmembrane potential was lower in Ca + Ni + Cd + H-Re group than that in 2-APB + Ca + Ni + Cd + H-Re and Ru + Ca + Ni + Cd + H-Re groups. CaR activation causes Ca2+ release from the SR into the mitochondria through IP3 Rs and induces cardiomyocyte apoptosis during hypoxia/reoxygenation.
Harbin Yike Daxue Xuebao published new progress about 226878-01-9. 226878-01-9 belongs to quinoxaline, auxiliary class Neuronal Signaling,mGluR, name is N-(Adamantan-1-yl)quinoxaline-2-carboxamide, and the molecular formula is C25H23NO4, Formula: C19H21N3O.
Referemce:
https://en.wikipedia.org/wiki/Quinoxaline,
Quinoxaline | C8H6N2 | ChemSpider