Month: November 2022

Perkampus, H. H. published an article in 1962, the title of the article was Ultraviolet absorption spectra of some simple quinoxaline derivatives.Synthetic Route of 62163-09-1 And the article contains the following content:

The UV spectra of the following quinoxaline derivatives were investigated in different solvents: 2-Me-, 2-Cl-, 2-MeO-. 2,3-di-Me-, 2,3-di-MeO-, 2,3-di-isopropoxy-, 2,3-di-Cl-, 2,3-di-Br-, 5- and 6-Me, 5- and 6-Cl, and 6,7-di-Me. Position, intensity, and assignment of the absorption bands and the fine structure of the 1Lb band are tabulated. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Synthetic Route of 62163-09-1

5-Chloroquinoxaline(cas:62163-09-1) belongs to quinoxaline. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands. Synthetic Route of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

On June 5, 2018, Jumal, Juliana; Ayomide, Adetunji Fridaos published an article.Related Products of 34413-35-9 The title of the article was Synthesis and radical scavenging activity of 6-hydroxyl-4-methylcoumarin and its derivatives. And the article contained the following:

Four compounds of coumarin derivatives namely 6-hydroxyl-4-methylcoumarin (I), 6-hydroxyl-4-methyl-5-(p-nitrophenyl azocoumarin) (II), 6-hydroxyl-4-methyl-5,7-(bis-p-nitrophenyl azocoumarin) (III) and 6-hydroxyl-4-methyl-5,7-(bis-p-chlorophenyl azocoumarin) (IV) were successfully synthesized. These compounds were prepared by reacting hydroquinone with ethylacetoacetate and selected anilines which are chloro and nitro aniline. All synthesized compounds were characterized by CHN micro-elemental anal., 1H NMR (NMR) and Fourier Transform IR (FTIR) spectroscopic methods. The IR spectra of these compounds exhibited five important stretching vibrations: (-OH), (C=O), (C=C), (C-O) and (C-N) at 3441-3359 cm-1, 1604-1632 cm-1, 1581-1496 cm-1, 1331-1225 cm-1, 1251-1109 cm-1, resp. 1H NMR spectra of these compounds show the presence of proton aromatic, proton Me and proton pyrone ring with the chem. shift at δH 7.00-8.70 ppm, δH 2.20-2.50 ppm and δH 6.10-6.90 ppm, resp. CHN anal. results of all compounds are in good agreement with the calculated values. All the synthesized compounds were evaluated for their antioxidant activity using DPPH method and ascorbic acid used as the standard UV-Vis spectroscopic technique was used to investigate the absorbance of these compounds Compound (II) shows high antioxidant activities compared to compound (I), (III) and (IV) which show moderate to low activities. The experimental process involved the reaction of 5,6,7,8-Tetrahydroquinoxaline(cas: 34413-35-9).Related Products of 34413-35-9

5,6,7,8-Tetrahydroquinoxaline(cas:34413-35-9) belongs to quinoxaline. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands. Related Products of 34413-35-9

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Landquist, Justus K. published an article in 1953, the title of the article was Quinoxaline N-oxides. I. The oxidation of quinoxaline and its Bz-substituted derivatives.Application of 62163-09-1 And the article contains the following content:

Quinoxaline (I) and its Bz-substituted-alkyl, alkoxy, halo, and acylamino derivatives are oxidized to 1- and 1,4-dioxides by organic peroxy acids. Resistance to N-oxidation is encountered in 5- and 8-substituted I. Reduction of 2,3-(O2N)2C6H3OEt with H and Raney Ni gave 3,1,2-EtOC6H3(NH2)2, oil (picrate, m. 210-12°). 2,4-Br(O2N)C6H3Me nitrated with HNO3 and H2SO4 at 40-5° gave 2,4,5-Br(O2N)2C6H2Me, m. 94-5°, which, treated with NH3 in alc. 5 h. at 120° and then reduced with Zn dust and NaOH in EtOH, yielded the 4,5-(H2N)2 analog, m. 140-1°. The following general procedure for preparation of I derivatives was used: (CHO.NaHSO3)2, an ο-phenylenediamine, and H2O were stirred 3 h. at 60°, then made alk. with KOH, and the I derivative was filtered off. The following derivatives were prepared (substituent, m.p., m.p. of 1-oxide, m.p. of 1,4-dioxide): 5-Me, 20-1°, b15, 120°, 131-2°, 192-4°; 5-EtO, 63-4°, b18 165-6°, 114-16°, -; 5-Cl (II), 60-2°, 177-9°, -; 6-iodo, 114-15°, -, -; 6-NC (III), 176-8°, -, -; 6,7-Me2, 100-1°, -, 220°; 6,7-benzo, 125-6°, -, -; 6,7-ClMe (IV), 120-2°, 166-8°, 227°; 6,7-BrMe (V), 127-8°, 167-8°, 222-4°; 6,7-Cl2 (VI), 210°, -, 206-8°; 5,8-Cl2 (VII), 205-7°, -, -; 6-Br (VIII)(prepared by the Sandmeyer reaction from the 6-NH2 compound), 48-9°, b18 146-9°, -, 223-5°; 6-AcNH (prepared from the 6-NH2 compound with Ac2O), 196.5°, -, 245-7°; 5-AcNH, -, 175-8°, 230-2° (insufficient for anal.). The following N-oxides were also prepared (substituent, m.p. 1-oxide, m.p. 1,4-dioxide): 6-Me (IX), -, 218-19°; 5,6-benzo, 158-9°, 215-16°; 5,6:7,8-dibenzo, 243-4°, -; 5-MeO, -, 222°; 6-MeO, -, 227-8°; 6-EtO, -, 192-4°; 5,6-(MeO)2, 138-40°, 220-2°; 6,7-(MeO)2, -, 264-5°; 2-Cl, 150-2°, -; 6-Cl (X), 151-2°, 211-12°. I is oxidized with equimolar AcO2H to quinoxaline 1-oxide, m. 122-3° (XI) while excess peroxy acid yields quinoxaline 1,4-dioxide, m. 241-3° (XII). Simultaneous with N-oxide formation there were obtained 2,3-dihydroxyquinoxalines which are listed below: (substituent, % yield, m.p.): IX, 1, 112°; II, 30, 142-3°; X, 15-30, 144°; VIII, 28, 132°; VII, 65, 160-1°; VI, 43, 170-70.5°; IV, 10, 172-3°; V, 12-6, 160-1°; III, 50, -; 6-O2N, 60, 150°. XI and MeI in MeCN set aside in the dark 36 h., precipitated 1-methylquinoxalinium iodide 4-oxide, m. 188-9°. XI was added cautiously to POCl3, and the mixture boiled 15 min. after the reaction subsided, poured on ice, made alk. with KOH, extracted with Et2O, and concentrated to yield 2-chloroquinoxaline, m. 46-8°. Under similar conditions XII yielded 2,3-dichloroquinoxaline; 5-methylquinoxaline 1-oxide gave 2-chloro-5-methylquinoxaline, m. 95°; and 5,6-benzoquinoxaline 1-oxide yielded 2-chloro-5,6-benzoquinoxaline, m. 120.5°. 2-C10H7NHCH2CO2Et dissolved treated in EtOH with PhN2Cl yielded 1,2-Ph2NC10H6NHCH2CO2Et, m. 135-6°, hydrogenated with Raney Ni at 60° and 50 atm. to 1,2,3,4-tetrahydro-2-oxo-7,8-benzoquinoxaline (XIII), m. 197-8°. XIII with alk. H2O2 gave 2-hydroxy-7,8-benzoquinoxaline, isolated as the hydrate, m. 275-5.5°, which was converted with POCl3 into 2-chloro-7,8-benzoquinoxaline, m. 128-9°. N-(6-nitro-o-tolyl)glycine in EtOH hydrogenated over Raney Ni at 60° and 60 atm. yielded 1,2,3,4-tetrahydro-5-methyl-2-oxoquinoxaline, m. 177-80°, readily oxidized to 2-hydroxy-5-methylquinoxaline, m. 282-3°. 2-Chloro-7,8-benzoquinoxaline and piperidine refluxed 1.5 h. gave 2-piperidino-7,8-benzoquinoxaline, m. 101.5-2.5°. 2-Piperidino-5,6-benzoquinoxaline, m. 124-5°, was similarly prepared Cl slowly passed 1 h. into 5,6-benzoquinoxaline in glacial HOAc, and the solution filtered and diluted with H2O yielded, on purification, dichloro-5,6-benzoquinoxaline, m. 187-8°. Methylation of 2,3-dihydroxy-6-nitroquinoxaline with Me2SO4 gave 3-hydroxy-1-methyl-6(or 7)-nitro-2(1H)-quinoxalinone, m. 344°. 6(or 7)-Cyano-3-hydroxy-1-methyl-2(1H)-quinoxalinone, m. 353-4°, is similarly prepared The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application of 62163-09-1

5-Chloroquinoxaline(cas:62163-09-1) belongs to quinoxaline. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands. Application of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Cheeseman, G. W. H.; Katritzky, A. R.; Ridgewell, B. J. published an article in 1963, the title of the article was The infrared spectra of polycyclic heteroaromatic compounds. III. 2-, 5-, and 6-substituted quinoxalines.Product Details of 62163-09-1 And the article contains the following content:

The infrared spectra of quinoxaline, 9 of its 2-substituted, 5 of its 5-substituted, and 8 of its 6-substituted derivatives are recorded and discussed, with tentative assignments of characteristic bands to specific mol. vibration modes. Cf. CA 56, 1073g. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Product Details of 62163-09-1

5-Chloroquinoxaline(cas:62163-09-1) belongs to quinoxaline. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands. Product Details of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Favini, Giorgio; Simonetta, Massimo published an article in 1960, the title of the article was Electronic transitions in the aromatic chlorazines. III. Absorption spectra of monochloro quinoxalines, phthalazines, quinazolines, and cinnolines.Synthetic Route of 62163-09-1 And the article contains the following content:

The absorption spectra of 2-, 5-, and 6-chloroquinoxalines (I, II, III), 2-, 4-, and 6-chloroquinazolines (IV, V, VI), 1-, 5-, and 6-chlorophthalazines (VII, VIII, IX), and 3-, and 4-cinnolines (X, XI) were measured in isoöctane and in MeOH between 220 and 450 mμ. Condensation of o-(H2N)2C6H4 and OC(CO2Et)2 and hydrolysis, decarboxylation of the 2-hydroxyquinoxaline-3-carboxylic acid and chlorination with POCl3 gave I, m. 46-7° (C5H12). Acetylation of o-ClC6H4NH2 and nitration with fuming HNO3, deacetylation of the crystalline 2,6-Cl-(O2N)C6H3NHAc with NaOH, reduction with SnCl2, and condensation of the reduction product with OHCCHO.(NaHSO3)2 yielded II, m. 61-2° (petr. ether). Similarly, com. 4,2-Cl(H2N)C6H3NH2 was transformed to III, m. 63-4° (petr. ether). Reduction of o-O2NC6H4CHO, condensation with urea, and chlorination of the 2-quinazolone with PCl3 and POCl3 gave IV, m. 108° (ligroine). HCONH2 condensed with o-H2NC6H4CO2H and the 4-quinazolone chlorinated with PCl5 and POCl3 successively yielded V, m. 99-100° (petr. ether). Nitration of 3-ClC6H4CHO and condensation with HCONH2 followed by reduction with Zn in AcOH gave VI, m. 145° (dilute alc.). Phthalide transformed through the Br derivative into o-OHCC6H4CO2H, condensed with N2H4.H2O to the phthalazone and chlorinated with POCl3 yielded VII, m. 110-11° (ligroine). Conversion of 3,4-Me2C6H3NH2 by the Sandmeyer reaction gave 10 g. 3,4-Me2C6H3Cl, converted through 3,4-(CHBr2)2C6H3Cl to 3,4-(OHC)2C6H3Cl and condensed with N2H4 to yield 0.4 g. IX, m. 132°. α-Tetrahydronaphthylamine (5 g.) converted according to Sandmeyer to α-chlorotetrahydronaphthalene and submitted to oxidative degradation, the isomeric mixture condensed with N2H4, the product chlorinated with POCl3 and the mixture of dichlorophthalazines (0.2 g.) treated with HI and P to eliminate the Cl of the heterocyclic ring gave a small amount of VIII. HCN added to o-O2NC6H4CHO and the nitrile saponified, the NO2 group reduced catalytically and the acid diazotized, reduced with SnCl2 and the 3-hydroxycinnoline chlorinated with POCl3 gave X, m. 90-1° (ligroine). MeCOPh nitrated and reduced with Sn and HCl, the o-H2NC6H4COMe diazotized and transformed into 4-hydroxycinnoline, treated successively with PCl5 and POCl3, and recrystallized from ligroine gave XI, m. 78-9°. The nature of the bands observed and the infuence exerted on the absorption maximum by introduction of an atom of Cl into the benzodiazine structure were discussed. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Synthetic Route of 62163-09-1

5-Chloroquinoxaline(cas:62163-09-1) belongs to quinoxaline. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands. Synthetic Route of 62163-09-1

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider

Favini, Giorgio; Simonetta, Massimo published an article in 1960, the title of the article was Electronic transitions in the aromatic chlorazines. II. Application of the method of Pariser and Parr to the azines of the monochlorinated benzene series.Application In Synthesis of 5-Chloroquinoxaline And the article contains the following content:

cf. CA 55, 7033g. The semiempirical method of Pariser and Parr was applied to PhCl (I), 2-, 3-, and 4-chloropyridines (II, III, IV), 2-, 3-, and 4-chloropyrimidines (V, VI, VII), chloropyrazine (VIII), and 3-chloropyridazine (IX). Comparison between theoretical and exptl. findings was limited to the values of energy transitions and oscillator strengths for the 1st singlet-singlet π-π’ transition. Monocentric and bicentric Coulomb integrals were calculated and tabulated. E was calculated for βCCl -0.86 and -2.50 without configuration interaction and with interaction of 5 and 8 configurations and the tabulated values were compared with exptl. values of ΔE. Oscillator strengths were calculated and similarly compared. The theory confirmed in all instances the bathochromic effect on the absorption maximum of the π-π’ transition caused by the introduction of an atom of Cl into C6H6 or an azine and, moreover gave shifts of the correct order of magnitude as shown by the tabulation (compound, Δν theoretical and exptl. (cm.-1) given): I, -870, -1350; II, -860, -1850; III, -1370, -2300; IV, -1830, -990; V, -1090, -1900; VI, -1730, -1250; VII, -2800, -2820; VIII, -970, -1460; IX, -2410, -1860. The experimental process involved the reaction of 5-Chloroquinoxaline(cas: 62163-09-1).Application In Synthesis of 5-Chloroquinoxaline

5-Chloroquinoxaline(cas:62163-09-1) belongs to quinoxaline. The antitumoral properties of quinoxaline compounds have been of interest. Recently, quinoxaline and its analogs have been investigated as the catalyst’s ligands. Application In Synthesis of 5-Chloroquinoxaline

Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider