Regioselectivity in the reaction of nitroquinoxaline N-oxides with phosphoryl chloride was written by Nasielski-Hinkens, R.;Vande Vyver, E.;Nasielski, J.. And the article was included in Bulletin des Societes Chimiques Belges in 1986.Safety of 6-Chloroquinoxaline This article mentions the following:
Oxidation of nitroquinoxalines I (n = 0; R, R1 = H, Me) by m-ClC6H4CO2OH gave their N-oxides; the NO2 group orients the O atom preferentially to N-1, but the N-4:N-1 selectivity is diminished in the methylated derivatives Meisenheimer reaction of I (n = 1, R = R1 = H) with POCl3 gave I (n = 0, R = Cl, R1 = H). The orientation of the entering Cl is discussed on the basis of electronic effects induced by the N-oxide and NO2 groups. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Safety of 6-Chloroquinoxaline).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline is isomeric with other naphthyridines including quinazoline, phthalazine and cinnoline. Quinoxaline-1,4-di-N-oxide derivatives have shown to improve the biological results and are endowed with anti-viral, anti-cancer, anti-bacterial, and anti-protozoal activities with application in many other therapeutic areas.Safety of 6-Chloroquinoxaline
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider