Quinoxaline chemistry. Part 12. 3-Carboxy-2-phenoxy-6(7)-substituted quinoxalines and N-[4-[6(7)-substituted-3-carboxyquinoxalin-2-yl]hydroxy]benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity was written by Vitale, Gabriella;Corona, Paola;Loriga, Mario;Paglietti, Giuseppe. And the article was included in Farmaco in 1998.SDS of cas: 49679-45-0 This article mentions the following:
Thirty quinoxalines I, bearing a substituted phenoxy or oxybenzoylglutamate group on position 2, a carbethoxy or carboxy group on position 3, and a trifluoromethyl group on position 6 or 7 of the heterocycle, were prepared in order to evaluate their in vitro anticancer activity. Screening of over 21 compounds showed that only a few derivatives exhibited a moderate growth inhibition activity on various tumor panel cell lines at a 10-4 molar concentration The acid derivatives showed no growth inhibition activity. The results obtained in this series indicate that, in general, carboxy or carbethoxy groups close to the O-link with Ph or benzoyl glutamates on position 2 are detrimental for anticancer activity. In the experiment, the researchers used many compounds, for example, Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0SDS of cas: 49679-45-0).
Ethyl 3-chloroquinoxaline-2-carboxylate (cas: 49679-45-0) belongs to quinoxaline derivatives. Quinoxalines have received a significant amount of attention due to their potential use in fighting various pathophysiological conditions like epilepsy, Parkinson’s, and Alzheimer’s diseases. The parent substance of the group, quinoxaline, results when glyoxal is condensed with 1,2-diaminobenzene. Substituted derivatives arise when α-ketonic acids, α-chlorketones, α-aldehyde alcohols and α-ketone alcohols are used in place of diketones.SDS of cas: 49679-45-0
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider