Direct C-2 arylation of quinoxaline with arylhydrazine salts as arylation reagents was written by Wang, Xing;Wang, Bing;Miao, Jing;Chen, Yi;Zhu, Gaofeng;Zhang, Jiquan;Wang, Jianta;Wang, Haibo;Tang, Lei;Wang, Cong. And the article was included in Journal of Heterocyclic Chemistry in 2022.Application of 5448-43-1 This article mentions the following:
A transition metal-free synthesis of 2-arylquinoxalines I (R = H, Me; R1 = H, Me, Cl; R2 = H, Me; R3 = Ph, 3-methylphenyl, 3-chloro-4-methylphenyl, pyridin-2-yl, etc.) is achieved by using arylhydrazine salt R3NHNH2.HCl as an aryl radical arylation reagent and air as an oxidant in the presence of K2CO3. This protocol is metal-free and environment friendly, has no additives, and mild reaction conditions, and can be used to construct biol. active mols. containing 2-phenylquinoxaline structure. In the experiment, the researchers used many compounds, for example, 6-Chloroquinoxaline (cas: 5448-43-1Application of 5448-43-1).
6-Chloroquinoxaline (cas: 5448-43-1) belongs to quinoxaline derivatives. Quinoxaline derivatives are important constituents of pharmacologically active compounds, including as well as for RNA synthesis inhibition, reactive dyes and pigments, azo dyes, flurox Cylin Dyes, Corrosion Inhibitors and Photovoltaic Polymers. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.Application of 5448-43-1
Referemce:
Quinoxaline – Wikipedia,
Quinoxaline | C8H6N2 | ChemSpider